99468-72-1

Usage

Uses

Used in Medical Plastic Industry:
3,5-BIS(TRIFLUOROMETHYL)-N-(BROMOACETYL)ANILINE is used as a raw material for the production of medical plastic pipes. Its chemical stability and biocompatibility make it suitable for use in medical applications where it comes into contact with bodily fluids or tissues.
Used in Agricultural Industry:
3,5-BIS(TRIFLUOROMETHYL)-N-(BROMOACETYL)ANILINE is used as a pesticide and herbicide. Its chemical properties allow it to effectively control pests and weeds, contributing to increased crop yields and reduced crop damage.

InChI:InChI=1/C10H6BrF6NO/c11-4-8(19)18-7-2-5(9(12,13)14)1-6(3-7)10(15,16)17/h1-3H,4H2,(H,18,19)

Upstream product

• 22118-09-8 2-bromoacetyl chloride 
• 328-74-5 3,5-Bis-(trifluoromethyl)aniline 
• 598-21-0 2-Bromoacetyl bromide 

Downstream Products

• 1170145-40-0 C₁₆H₁₈F₆N₂O 
• 1401333-74-1 C₂₂H₂₃F₆N₃O 
• 1269773-40-1 N-(3,5-bis(trifluoromethyl)phenyl)-2-(piperazin-1-yl)acetamide hydrochloride 
• 1401333-72-9 C₂₁H₂₁F₆N₃O 
• 1269773-69-4 tert-butyl 4-(2-(3,5-bis(trifluoromethyl)phenylamino)-2-oxoethyl)piperazine-1-carboxylate 
• 329778-87-2 C₂₀H₁₉F₆N₃O 
• 445231-68-5 C₁₆H₁₁F₆NOS 

Relevant academic research and scientific papers

Discovery and evolution of 12N-substituted aloperine derivatives as anti-SARS-CoV-2 agents through targeting late entry stage

So far, there is still no specific drug against COVID-19. Taking compound 1 with anti-EBOV activity as the lead, fifty-four 12N-substituted aloperine derivatives were synthesized and evaluated for the anti-SARS-CoV-2 activities using pseudotyped virus model. Among them, 8a exhibited the most potential effects against both pseudotyped and authentic SARS-CoV-2, as well as SARS-CoV and MERS-CoV, indicating a broad-spectrum anti-coronavirus profile. The mechanism study disclosed that 8a might block a late stage of viral entry, mainly via inhibiting host cathepsin B activity rather than directly targeting cathepsin B protein. Also, 8a could significantly reduce the release of multiple inflammatory cytokines in a time- and dose-dependent manner, such as IL-6, IL-1β, IL-8 and MCP-1, the major contributors to cytokine storm. Therefore, 8a is a promising agent with the advantages of broad-spectrum anti-coronavirus and anti-cytokine effects, thus worthy of further investigation.

Structure–activity relationship and biological evaluation of 12 N-substituted aloperine derivatives as PD-L1 down-regulatory agents through proteasome pathway

Twenty-nine 12 N-substituted aloperine derivatives were synthesized and screened for suppression on PD-L1 expression in H460 cells, as a continuation of our work. Systematic structural modifications led to the identification of compound 6b as the most act

Amide-Based Cinchona Alkaloids as Phase-Transfer Catalysts: Synthesis and Potential Application

Herein we present a library of simple amide derivatives of Cinchona alkaloids in the form of quaternary ammonium salts. The obtained derivatives can be generated very easily and efficiently from inexpensive and commercially available substrates. We tested this class of alkaloids in the alkylation of glycine derivative, carried out under phase-transfer catalyst conditions. The presented hybrid catalysts offer both high reaction yields (up to 97%) and high enantioselectivities of the obtained product (up to 94% ee).

The design and synthesis of 1,4-substituted piperazine derivatives as triple reuptake inhibitors

Novel 1,4-substituted piperazine derivatives 5, Series A and B were designed by fragment analysis and molecular modification of 4 selected piperazine-containing compounds which possess antidepressant activity. We synthesized new 39 analogues of Series A and 10 compounds of Series B, respectively. The antidepressant screening against DA, NE, and serotonin neurotransmitter uptake inhibition was carried out using the Neurotransmitter Transporter Uptake Assay Kit. The compounds in Series B showed relatively higher reuptake inhibitory activity for SERT, NET, and DAT than those in Series A. The length of spacer between the central piperazine core and the terminal phenyl ring substituted at the piperazine ring in Series B seems to exert an important role in the activity.

Bronsted base/Lewis acid cooperative catalysis in the enantioselective Conia-ene reaction

(Chemical Equation Presented) A mutually compatible and cooperative combination of copper(I) triflate and bifunctional 9-amino-9-deoxyepicinchona- derived urea compounds for the enantioselective Conia-ene cyclization of alkyne-tethered β-ketoester substrates is reported. The reaction is efficient, broad in scope, and easy to perform and allows access to chiral methylenecyclopentane products with high enantiocontrol. The transformation illustrates the concept of combining inactive precatalysts with inactive transition-metal-ion complexes in situ to reversibly create a catalytically active combination of the two.