99481-32-0Relevant academic research and scientific papers
Colchicine derivative as well as preparation method and application thereof
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Paragraph 0014; 0039-0041, (2021/06/26)
The invention discloses a colchicine derivative as well as a preparation method and application thereof, and belongs to the technical field of medicines. A low-toxicity colchicine derivative is prepared and then compounded with phospholipid to prepare a phospholipid complex, a sialic acid derivative is adopted to modify the surface of the phospholipid complex to endow the phospholipid complex with targeting property, and the phospholipid complex is used for preparing an anti-tumor safer and more effective colchicine derivative injection. According to the invention, the sialic acid derivative is modified on the surface of the phospholipid complex compounded by the colchicine derivative and the phospholipid, so that the phospholipid complex can be stabilized, and a nano carrier is endowed with neutrophile granulocyte targeting property, so that the colchicine derivative can be used for preparing an active targeting nano dosage form medicine for treating tumors.
N-DIDEUTEROBUTYRYLDEACETYLCOLCHICINE: PROBES TO STUDY COLCHICINE BINDING SITES ON TUBULIN PROTEIN
Iorio, Maria A.,Doldo, Antonio,Brossi, Arnold,Chignell, Colin F.
, p. 2577 - 2581 (2007/10/02)
N-Acryloyl- and N-crotonyldeacetylcolchicine prepared from deacetylcolchiceine by conventional methods showed good binding to tubulin protein in vitro.N-Dideuterobutyryldeacetylcolchicine, prepared from deacetylcolchicine with dideuterobutyryl chloride behaved similarly, suggesting that tritiated analogs of N-propionyl- and N-butyryldeacetylcolchicine should be useful probes to study the colchicine binding site on tubulin protein.
