99481-69-3Relevant academic research and scientific papers
Synthesis of Quaternary α-Fluorinated α-Amino Acid Derivatives via Coordinating Cu(II) Catalytic α-C(sp3)-H Direct Fluorination
Wei, Qiang,Ma, Yao,Li, Li,Liu, Qingfei,Liu, Zijie,Liu, Gang
supporting information, p. 7100 - 7103 (2018/11/24)
A coordinating, copper-catalyzed direct α-C(sp3)-H fluorination method has been developed to prepare vital quaternary α-fluorinated α-amino acid derivatives. A Cu(II) catalytic SET oxidative addition mechanism is proposed, involving a key fluoride-coupled Cu(II) charge transfer complex. The protocol can tolerate a rich variety of α-amino acids, for which the auxiliary group is removed in high yield and substituted for the direct preparation of dipeptide derivatives with detachable, single absolute configurations of the target compounds.
SYNTHESIS AND REACTIONS OF PHTHALIMIDO ALIPHATIC ACID AZIDES
Essawy, Samy A.,El-Aleem, A. H. Abd,Donia, S. G.,Metwally, R. N.
, p. 1243 - 1250 (2007/10/02)
Azides (2a-d), in the base catalyzed decomposition with aromatic amines yielded the corresponding N-aryl-N'-alkyl ureas (4a-t) via Curtius rearrangement.However, the base catalyzed decomposition of 2 with phenylhydrazine took place via azido group displacement to afford phthalimido aliphatic acid phenylhydrazides (8a-d).Decomposition of azides (2a-d) in neutral medium yielded the corresponding sym-N,N'-di-alkyl ureas (9a-d), via Curtius rearrangement.
