99512-01-3Relevant articles and documents
Total Synthesis of a Novel Antiulcer Agent via a Modification of the Intramolecular Wadsworth-Emmons-Wittig Reaction
Aristoff, Paul A.,Johnson, Paul D.,Harrison, Allen W.
, p. 7967 - 7974 (1985)
A convergent synthesis of the novel, potent antiulcer agent U-68,215 (3), a benzindene prostacyclin analogue, is described.U-68,215 is prepared via a cyclopentane annulation sequence in optically pure form in 14 steps and 12percent yield from 5-methoxy-2-