Journal of the American Chemical Society p. 7967 - 7974 (1985)
Update date:2022-08-03
Topics:
Aristoff, Paul A.
Johnson, Paul D.
Harrison, Allen W.
A convergent synthesis of the novel, potent antiulcer agent U-68,215 (3), a benzindene prostacyclin analogue, is described.U-68,215 is prepared via a cyclopentane annulation sequence in optically pure form in 14 steps and 12percent yield from 5-methoxy-2-
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