Total Synthesis of a Novel Antiulcer Agent via a Modification of the Intramolecular Wadsworth-Emmons-Wittig Reaction

DOI: 10.1021/ja00312a028

Source and publish data:

Journal of the American Chemical Society p. 7967 - 7974 (1985)

Update date:2022-08-03

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Authors:

Aristoff, Paul A.

Johnson, Paul D.

Harrison, Allen W.

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Article abstract of DOI:10.1021/ja00312a028

A convergent synthesis of the novel, potent antiulcer agent U-68,215 (3), a benzindene prostacyclin analogue, is described.U-68,215 is prepared via a cyclopentane annulation sequence in optically pure form in 14 steps and 12percent yield from 5-methoxy-2-

Full text of DOI:10.1021/ja00312a028

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