99512-15-9

Upstream product

• 32271-56-0 (E)-4-(4-chlorophenyl)but-3-en-2-ol 
• 108-24-7 acetic anhydride 
• 101671-01-6 1-nitro-2-(4-chlorophenyl)ethylene 
• 141-78-6 ethyl acetate 
• 39212-13-0 (E)-1-phenyl-3-(4-methoxyphenyl)prop-2-en-1-ol 
• 126613-18-1 1-(benzenesulfonyl)-2-(p-chlorophenyl)acetylene 
• 104-88-1 4-chlorobenzaldehyde 
• 30626-03-0 (3E)-4-(4-chlorophenyl)-3-buten-2-one 

Downstream Products

• 33356-84-2 (E)-1-(buta-1,3-dien-1-yl)-4-chlorobenzene 
• 331866-60-5 (2R,3E)-4-(4-chlorophenyl)-3-buten-2-ol 
• 1380438-77-6 (-)-(R)-(E)-3-(4-(4-chlorophenyl)but-3-en-2-yl)furan-2(5H)-one 
• 1592889-62-7 (E)-1-chloro-4-(hepta-1,5-dien-4-yl)benzene 
• 1592889-82-1 (E)-1-chloro-4-(3-methylhexa-1,5-dien-1-yl)benzene 

Relevant academic research and scientific papers

Site-Selective α-Alkoxyl Alkynation of Alkyl Esters Mediated by Boryl Radicals

A novel method for site-selective C-H functionalization of ethyl acetate mediated by pyridine-boryl radicals is presented, delivering a variety of 4-phenylbut-3-yn-2-yl acetate derivatives under mild conditions. A distinguishing feature of this reaction i

Catalytic stereospecific allyl-allyl cross-coupling of internal allyl electrophiles with allylB(pin)

Application of internal electrophiles in catalytic stereospecific allyl-allyl cross-coupling enable the rapid construction of multisubstituted 1,5-dienes, including those with all carbon quaternary centers. Compounds with minimal steric differentiation ca

Highly enantioselective synthesis of 3-substituted furanones by palladium-catalyzed kinetic resolution of unsymmetrical allyl acetates

Resolving the issue: A near-perfect Pd-catalyzed kinetic resolution of 1,3-disubstituted unsymmetrical allylic acetates uses silyl enol ethers as nucleophiles to access the important 3-substituted-furanone scaffold (see scheme; DACH=diaminocyclohexyl, dba=dibenzylideneacetone). The reaction proceeds under mild conditions and provides the desired products with excellent chemo-, regio-, and enantioselectivity. Copyright

Radical reactions in esters with alkoxy functionality chemistry an unusual alcohol moiety hydrogen abstraction

Various geometrically pure (E)-alkenes have been synthesized by radical substitution of alcohol moieties generated via hydrogen abstraction within ethyl esters. These reactions occurred with high regioselectivity and gave a new access to 1-methyl-3-aryl-allyl esters.

Enantioselective synthesis of β-substituted butyric acid derivatives via orthoester Claisen rearrangement of enzymatically resolved allylic alcohols: Application to the synthesis of (R)-(-)-baclofen

A three step synthesis of (R)-(-)-baclofen is described. The key step is the orthoester Claisen rearrangement of enantiopure allylic alcohol (S,E)-(-)-1a, affording γ,δ-unsaturated ester (S,E)-(+)-6 with high stereoselectivity. This latter derivative is converted into (R)-(-)-baclofen through a high yield one-pot reaction.