99513-18-5

Upstream product

• 3323-76-0 1-(2-Methanesulfonyl-phenyl)-ethanone 
• 2142-70-3 2-iodoacetophenone 
• 75473-10-8 2-Mesylbenzoyl-malonsaeurediethylester 
• 49639-13-6 2-methylsulfonylbenzoyl chloride 

Downstream Products

• 75473-45-9 5-(2-Methanesulfonyl-phenyl)-7-nitro-1,3-dihydro-thieno[2,3-e][1,4]diazepin-2-one 
• 75473-44-8 7-Chloro-5-(2-methanesulfonyl-phenyl)-1,3-dihydro-thieno[2,3-e][1,4]diazepin-2-one 
• 75473-18-6 2-Chloro-N-[3-(2-methanesulfonyl-benzoyl)-thiophen-2-yl]-acetamide 
• 75473-36-8 2-Amino-N-[3-(2-methanesulfonyl-benzoyl)-thiophen-2-yl]-acetamide 
• 75473-23-3 2-Iodo-N-[3-(2-methanesulfonyl-benzoyl)-thiophen-2-yl]-acetamide 
• 75473-33-5 5-(2-Methanesulfonyl-phenyl)-1,3-dihydro-thieno[2,3-e][1,4]diazepin-2-one 
• 75473-13-1 (2-Amino-thiophen-3-yl)-(2-methanesulfonyl-phenyl)-methanone 
• 75473-07-3 3-(2-(Methylsulphonyl)phenyl)-3-oxopropanenitrile 

Relevant academic research and scientific papers

NADPH OXIDASE INHIBITORS, PHARMACEUTICAL COMPOSITION COMPRISING THE SAME, AND APPLICATION THEREOF

The present disclosure relates to a compound of Formula I, or a geometric isomer, enantiomer, diastereomer, racemate, atropisomer, pharmaceutically acceptable salt, prodrug or solvate thereof. The present disclosure further relates to a composition comprising the compound of Formula (I). The compound and the composition described herein can be used to inhibit NADPH oxidase activity.

Thiazole benzamide derivatives and pharmaceutical compositions for inhibiting cell proliferation, and methods for their use

Aminothiazole compounds with mono-/di-substituted benzamide are represented by the Formula (I), and their pharmaceutically acceptable salts, pharmaceutically acceptable prodrugs, pharmaceutically active metabolites, and pharmaceutically acceptable salts of said metabolites are described. These agents modulate and/or inhibit the cell proliferation and activity of protein kinases and are useful as pharmaceuticals for treating malignancies and other disorders.