99517-98-3 Usage
Uses
Used in Gene Regulation Applications:
3-(2'-Deoxy-β-D-2-ribofuranosyl)pyrido[2,3-d]pyrimidine-2,7(8H)-dione is used as a key component in the design of triple helix-forming oligonucleotides (TFOs) for the purpose of specifically modulating gene expression. Its incorporation into TFOs enhances the potential to target and regulate genes in a sequence-dependent manner, offering a promising approach for various therapeutic applications.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 3-(2'-Deoxy-β-D-2-ribofuranosyl)pyrido[2,3-d]pyrimidine-2,7(8H)-dione is utilized as a building block for the development of novel therapeutic agents. Its ability to modulate gene expression makes it a valuable tool in the creation of drugs that can target specific genetic pathways, potentially leading to more effective treatments for various diseases.
Used in Biotechnology Research:
3-(2'-Deoxy-β-D-2-ribofuranosyl)pyrido[2,3-d]pyrimidine-2,7(8H)-dione is also used in biotechnology research as a means to study and understand the mechanisms of gene regulation. Its role in the formation of triple helix-forming oligonucleotides (TFOs) allows researchers to explore the potential of sequence-specific gene modulation, which can contribute to advancements in genetic engineering and gene therapy.
Check Digit Verification of cas no
The CAS Registry Mumber 99517-98-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 9,9,5,1 and 7 respectively; the second part has 2 digits, 9 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 99517-98:
(7*9)+(6*9)+(5*5)+(4*1)+(3*7)+(2*9)+(1*8)=193
193 % 10 = 3
So 99517-98-3 is a valid CAS Registry Number.
99517-98-3Relevant academic research and scientific papers
Zhou, Qian,Li, Kun,Yu, Kang-Kang,Li, Na,Shi, Lei,Chen, Hao,Chen, Shan-Yong,Yu, Xiao-Qi
, p. 12158 - 12161 (2020)
A highly reactive ylidetBuAwas introduced, which could react rapidly with the 5-formyl and 4-amino groups of 5-formylcytosine (5fC) under mild conditions without any co-solvent or catalyst in a manner of Wittig olefination and intramolecular nucleophilic substitution to yield a cyclized fluorescent adduct, which meets the demands of both single-base resolution sequencing and fluorescence switch-on detection of 5fC in DNA.
