99552-32-6

Usage

Uses

Used in Laboratory Research:
N-(2,4-dimethylphenyl)piperidine-2-carboxamide is utilized as a chemical building block or intermediate for the synthesis of other compounds, playing a crucial role in advancing scientific studies and the development of new chemical entities.
Used in Pharmacology and Medicinal Chemistry:
In the field of pharmacology and medicinal chemistry, N-(2,4-dimethylphenyl)piperidine-2-carboxamide is employed for its capacity to interact with biological systems, which positions it as a promising candidate for the creation of novel therapeutic agents.
Used in Chemical Synthesis:
N-(2,4-dimethylphenyl)piperidine-2-carboxamide is used as a key intermediate in the synthesis of a variety of chemical products, contributing to the diversification of chemical libraries and the discovery of new molecules with potential applications.

Upstream product

• 95-68-1 2,4-Xylidine 
• 3105-95-1 pipecolinic acid 
• 130606-00-7 piperidine-2-carbonyl chloride 
• 15862-86-9 piperidine-2-carboxylic acid hydrochloride 

Relevant academic research and scientific papers

Synthesis, Characterization and Biological Evaluation of Some Novel Regioisomers of Ropivacaine Analogues: An Anaesthetic Drug

A series of ropivacaine analogues were synthesized by altering the methyl group substituent in the aromatic ring. The synthesized compounds (2a-f and 3a-f) were characterized by using IR, NMR and HRMS analysis and then compounds 3a-3f were screened in vitro anticancer (MTT assay) activity against breast cancer cell line (MCF-7), antibacterial and antioxidant (DPPH scavenging assay) studies. The biological studies revealed that the compounds 3c and 3f have shown a good inhibitory activity against MCF-7 cell line. Compounds 3e, 3b, 3c and 3f showed moderate antioxidant activity. There was no inhibition observed against both Gram-positive and Gram-negative bacteria.

Synthesis of 2-piperidinecarboxylic acid derivatives as potential anticonvulsants

A variety of 2-piperidinecarboxamides were synthesized and evaluated for anticonvulsant activity using the MES and sc PTZ tests in mice and rats. Neurotoxicity was determined by the rotorod test. Several N-(benzyl)-2- piperidinecarboxamides exhibited potent MES activity in mice [2-CF3 14, ED50 = 29 mg/kg; 3-F 16, ED50 = 31 mg/kg; and 3-CF3 17, ED50 = 24 mg/kg]. The most active compounds in the MES test in mice were the 2,6- dimethylanilides [(R,S)-34, ED50 = 5.8 mg/kg; (R)-35, ED50 = 5.7 mg/kg; and (S)-36, ED50 = 14.8 mg/kg]. The enantiomer (S)-36 was about two-fold less potent in the MES test than (R)-35 and also was less neurotoxic. Acylation of the piperidine ring nitrogen of 12 anal 34 led to a decrease in the MES activity. In the N-(α-methylbenzyl)-2-piperidine-carboxamides, the stereochemistry at either the 2-position of the piperidine ring or at the α- position of the N-(α-methylbenzyl) group does not significantly affect MES activity.