99556-74-8

Usage

General Description

3-Methoxy-4-[2-(1-pyrrolidinyl)ethoxy]benzaldehyde oxalate is a chemical compound that consists of a benzaldehyde group attached to a methoxy and a pyrrolidinyl ethoxy group. The oxalate salt of 3-METHOXY-4-[2-(1-PYRROLIDINYL)ETHOXY]BENZALDEHYDE OXALATE is commonly used in research and as a building block for the synthesis of other organic compounds. It is often utilized in medical and pharmaceutical research for its potential as a precursor or intermediate in the development of new drugs and medications. The compound is known for its ability to undergo various chemical reactions and is a valuable tool in the field of organic chemistry.

InChI:InChI=1/C14H19NO3/c1-17-14-10-12(11-16)4-5-13(14)18-9-8-15-6-2-3-7-15/h4-5,10-11H,2-3,6-9H2,1H3

Upstream product

• 121-33-5 vanillin 
• 123-75-1 pyrrolidine 
• 99070-23-2 4-(2-bromo-ethoxy)-3-methoxy-benzaldehyde 
• 5050-41-9 N-(2-chloroethyl)-pyrrolidine 
• 7250-67-1 1-(2-chloroethyl)pyrrolidine hydrochloride 

Downstream Products

• 1151468-91-5 16-[3-methoxy-4-{2-(pyrrolidin-1-yl)ethoxy}-benzylidene]-17-oxo-5-androsten-3β-ol 
• 1097725-87-5 6-amino-5-[6'-amino-1',3'-dimethyl-2',4'-dioxo-1',2',3',4'-tetrahydro-5'-pyrimidinyl{4-[2-(1-pyrrolidinyl)ethoxy]-3-methoxyphenyl}methyl]-1,3-dimethyl-1,2,3,4-tetrahydro-2,4-pyrimidinedione 
• 1155224-19-3 6-amino-5-[{3-methoxy-4-(2-pyrrolidin-1-ylethoxy)benzylidene}amino]-1,3-dimethyluracil 
• 1228797-63-4 2-[3-methoxy-4-(2-pyrrolidin-1-yl-ethoxy)benzylidene]-indan-1-one 

Relevant academic research and scientific papers

Bronchospasmolytic activity and adenosine receptor binding of some newer 1,3-dipropyl-8-phenyl substituted xanthine derivatives

The aldehyde derivatives of 1,3-dipropyl xanthines as described in this paper, constitutes a new series of selective adenosine ligands displaying bronchospasmolytic activity. The effect of substitution at third- and fourth-position of 8-phenyl xanthine ha

With tyrosine kinase inhibitory activity of 2 - indolone derivatives and its preparation method and application

The invention discloses a 2-indolone derivative with tyrosine kinase inhibition activity, geometric isomers and medicinal salts thereof, and a preparation method and an application of the above compounds. Tyrosine kinase inhibition activity evaluation confirms that the derivative is a compound with good tyrosine kinase activity, so the derivative has potential antitumor activity, and can be used to prepare tumor disease prevention and treatment medicines (antitumor medicines) as an active component. The derivative provides research and enforcement foundation for tumor treatment, and has a wide application prospect.

Synthesis and Evaluation of a New Series of 8-(2-Nitroaryl)Xanthines as Adenosine Receptor Ligands

(Table presented.). A new series of 1,3-dimethylxanthine derivatives bearing 8-(2-nitroaryl) residue was synthesized and evaluated for affinity for recombinant human adenosine receptors subtypes. Nitrate esters of 7-substituted-1,3-dimethyl-8-phenylxanthines were also synthesized and tested. Introducing a nitro substituent at the 2-position of the 8-substituted phenyl ring resulted in generally low affinity for adenosine receptors (ARs), selectivity toward the A2A subtype was enhanced in some of the compounds. 8-(4-Cyclopentyloxy-5-methoxy-2-nitrophenyl)-1,3-dimethylxanthine (9e) proved to be a potent compound among the 2-nitrophenyl substituted xanthines exhibiting a Ki = 1 μM at human A2A ARs with at least 30 fold selectivity versus human A1 and A2B ARs. Replacement of 8-chloropropoxy phenyl with 8-nitrooxypropoxy phenyl resulted in a negligible change in binding affinity of the 8-substituted xanthines for various AR subtypes. Drug Dev Res 77 : 241–250, 2016.

Synthesis of some imidazolyl-substituted 2-benzylidene indanone derivatives as potent aromatase inhibitors for breast cancer therapy

The synthesis and aromatase inhibitory activity of a new series of 2-benzylidene indanones is presented. The imidazolyl-substituted indanones displayed potent aromatase inhibitory activity. The vanilloid-based derivative 2-[4-(3-imidazol-1-ylpropoxy)-3-me

Synthesis of a series of 8-(substituted-phenyl)xanthines and a study on the effects of substitution pattern of phenyl substituents on affinity for adenosine A1 and A2A receptors

A new series of 8-(substituted-phenyl)xanthines have been synthesized and compounds were evaluated for their affinity for A1 and A2 adenosine receptors (AR) using radioligand binding assays. The effects of varying the positions of 8-phenyl substituents on affinity and selectivity at A1 and A2A adenosine receptors have been studied. Isovanilloid 1,3-dimethyl-8-[4-methoxy-3-(2-morpholin-4-ylethoxy)phenylxanthine (9d) displayed the highest affinity and selectivity towards A2A AR subtypes with Ki = 100 nM over A1 receptors (Ki > 100 mM). It has been observed that substitution pattern on 8-phenyl group greatly affects the affinity and selectivity at adenosine receptors, with A2A tolerating bulkier substituents than did A1 receptors.

Synthesis of 16E-[3-methoxy-4-(2-aminoethoxy)benzylidene]androstene derivatives as potent cytotoxic agents

The synthesis and cytotoxic studies of a new series of 16E-arylidene androstene derivatives are reported herein. The impact of incorporating bis-tertiary amino functionalities in the steroid skeleton on cytotoxicity has also been observed. The compounds have been evaluated at National cancer Institute, Bethesda, Maryland, USA for their antineoplastic activity against various tumor cell lines. The synthesized 16E-arylidenosteroids exhibited significant cytotoxicity. Bis-tertiary amino steroid 29 possessing a diethylaminoalkoxy functionality was the most promising compound of the series with a total IP and SC score of 20 in in vivo hollow fiber assay and was selected for further detailed in vivo xenograft testing.

Formation of aryl-bis (6-amino-1,3-dimethyluracil-5-yl) methanes by reaction of 6-amino-1,3-dimethyluracil with aromatic aldehydes

(Chemical Equation Presented) The synthesis of aryl-bis(6-amino-1,3- dimethyluracil-5-yl)-methanes 3a-m by condensation of 6-amino-1,3-dimethyluracil (1) with aromatic aldehydes 2a-m at room temperature is reported. The structures of the compounds were es