99573-14-5

Upstream product

• 67-56-1 methanol 
• 92611-29-5 4-(2-bromophenyl)-5-methylpyridine-2,3,6-tricarboxylic acid 
• 64-17-5 ethanol 
• 92628-24-5 triethyl 4-(2-bromophenyl)-5-methylpyridine-2,3,6-tricarboxylate 

Downstream Products

• 92611-31-9 3-amino-4-(2-bromophenyl)-2,6-bis(methoxycarbonyl)-5-methylpyridine 

Relevant academic research and scientific papers

Inverse Electron Demand Diels-Alder Reactions of Heterocyclic Aza Dienes. Studies on the Total Synthesis of Lavendamycin: Investigative Studies on the Preparation of the CDE β-Carboline Ring System and AB Quinoline-5,8-quinone Ring System

The investigation and utilization of the inverse electron demand cycloaddition of 3,5,6-tris(ethoxycarbonyl)-1,2,4-triazine with electron-rich olefins and the subsequent implementation of a palladium(0)-mediated β-carboline synthesis for the preparation of the CDE ring system of lavendamycin are detailed.Studies on the introduction and preparation of the 7-aminoquinoline-5,8-quinone AB ring system of lavendamycin are described.

PALLADIUM (0) MEDIATED β-CARBOLINE SYNTHESIS: PREPARATION OF THE CDE RING SYSTEM OF LAVENDAMYCIN

A five-step approach to the preparation of the β-carboline CDE ring system of lavendamycin is detailed and is based on: (1) thermal cycloaddition of 3,5,6-tricarbomethoxy-1,2,4-triazine with the pyrrolidine enamine of o-bromopropiophenone followed by (2) implementation of a newly developed palladium (0) mediated β-carboline synthesis.