99573-17-8

Upstream product

• 37524-01-9 methyl 4-bromo-2-nitro-3-hydroxybenzoate 
• 100-39-0 benzyl bromide 
• 14348-38-0 4-bromo-3-hydroxybenzoic acid 
• 37524-08-6 4-bromo-2-nitro-3-hydroxybenzoic acid 

Downstream Products

• 99573-20-3 2-Amino-3-(benzyloxy)-4-bromobenzaldehyde 
• 99573-19-0 3-(benzyloxy)-4-bromo-2-nitrobenzaldehyde 
• 99573-21-4 8-(benzyloxy)-7-bromo-2-(2'-pyridyl)quinoline 
• 99582-51-1 C₃₂H₂₂N₃O₂P 
• 99573-18-9 3-(benzyloxy)-4-bromo-2-nitrobenzyl alcohol 

Relevant academic research and scientific papers

Inverse Electron Demand Diels-Alder Reactions of Heterocyclic Aza Dienes. Studies on the Total Synthesis of Lavendamycin: Investigative Studies on the Preparation of the CDE β-Carboline Ring System and AB Quinoline-5,8-quinone Ring System

The investigation and utilization of the inverse electron demand cycloaddition of 3,5,6-tris(ethoxycarbonyl)-1,2,4-triazine with electron-rich olefins and the subsequent implementation of a palladium(0)-mediated β-carboline synthesis for the preparation of the CDE ring system of lavendamycin are detailed.Studies on the introduction and preparation of the 7-aminoquinoline-5,8-quinone AB ring system of lavendamycin are described.

TRICYCLIC HETEROCYCLES AS BET PROTEIN INHIBITORS

The present invention relates to tricyclic heterocycles which are inhibitors of BET proteins such as BRD2, BRD3, BRD4, and BRD-t and are useful in the treatment of diseases such as cancer.