99584-10-8

Basic information

• Product Name: 6-Amino-3-methyl-1,3-benzoxazol-2(3H)-one, 90%
• Synonyms: 6-Amino-3-methyl-1,3-benzoxazol-2(3H)-one, 90%;6-amino-3-methyl-1,3-benzoxazol-2(3H)-one(SALTDATA: FREE);6-amino-3-methyl-1,3-benzoxazol-2-one
• CAS NO: 99584-10-8
• Molecular Formula: C₈H₈N₂O₂
• Molecular Weight: 164
• Mol File: 99584-10-8.mol
• Article Data: 9

Chemical Properties

• Appearance: Tan/Powder
• CAS DataBase Reference: 6-Amino-3-methyl-1,3-benzoxazol-2(3H)-one, 90%(CAS DataBase Reference)
• NIST Chemistry Reference: 6-Amino-3-methyl-1,3-benzoxazol-2(3H)-one, 90%(99584-10-8)
• EPA Substance Registry System: 6-Amino-3-methyl-1,3-benzoxazol-2(3H)-one, 90%(99584-10-8)

Safety Data

• Hazardous Substances Data: 99584-10-8(Hazardous Substances Data)

Usage

General Description

The chemical 6-Amino-3-methyl-1,3-benzoxazol-2(3H)-one, 90% is a white crystalline powder with a purity of 90%. It is a derivative of benzoxazole and contains an amino group and a methyl group on the benzoxazole ring. This chemical is commonly used as a building block in the synthesis of pharmaceuticals, agrochemicals, and other organic compounds. It may also have potential applications in research and development in the fields of medicinal chemistry and chemical biology. Additionally, it is important to handle this chemical with care and following proper safety procedures, as with any potentially hazardous chemical.

Upstream product

• 121-88-0 5-Nitro-2-aminophenol 
• 95-55-6 2-amino-phenol 
• 21892-80-8 3-methylbenzo[d]oxazol-2(3H)-one 
• 59-49-4 2-Benzoxazolinone 
• 4694-91-1 6-nitro-3H-benzooxazol-2-one 
• 186581-53-3 diazomethane 
• 22876-17-1 6-amino-1,3-benzoxazol-2-(3H)-one 
• 101084-61-1 3-methyl-6-nitrobenzo[d]oxazole-2(3H)-one 

Downstream Products

• 1383813-04-4 1-(2-phenylethyl)-3-(3-methyl-2-oxo-3H-benzoxazole-6-yl)urea 
• 1383813-13-5 1-(2-phenylethyl)-3-(3-methyl-2-oxo-3H-benzoxazole-6-yl)thiourea 
• 1383813-12-4 1-benzyl-3-(3-methyl-2-oxo-3H-benzoxazole-6-yl)thiourea 
• 1223984-74-4 1-(4-chlorophenyl)-3-(3-methyl-2-oxo-3H-benzoxazole-6-yl)urea 
• 1223908-82-4 1-phenyl-3-(3-methyl-2-oxo-3H-benzoxazole-6-yl)urea 
• 1383813-09-9 1-phenyl-3-(3-methyl-2-oxo-3H-benzoxazole-6-yl)thiourea 
• 1383813-10-2 1-(4-chlorophenyl)-3-(3-methyl-2-oxo-3H-benzoxazole-6-yl)thiourea 
• 1224013-34-6 1-(4-methoxyphenyl)-3-(3-methyl-2-oxo-3H-benzoxazole-6-yl)urea 
• 1383813-11-3 1-(4-methoxyphenyl)-3-(3-methyl-2-oxo-3H-benzoxazole-6-yl)thiourea 
• 1223916-05-9 1-benzyl-3-(3-methyl-2-oxo-3H-benzoxazole-6-yl)urea 
• 1488354-15-9 1-(3-methyl-2-oxo-2,3-dihydro-1,3-benzoxazol-6-yl)-2,4-dioxo-3-[(1R)-4-(trifluoromethyl)-2,3-dihydro-1H-inden-1-yl]-1,2,3,4-tetrahydropyrimidine-5-carboxylic acid 
• 1488354-15-9 1-(3-methyl-2-oxo-2,3-dihydro-1,3-benzoxazol-6-yl)-2,4-dioxo-3-[(1S)-4-(trifluoromethyl)-2,3-dihydro-1H-inden-1-yl]-1,2,3,4-tetrahydropyrimidine-5-carboxylic acid 

Relevant articles and documents

Design, synthesis and biological evaluation of new benzoxazolone/benzothiazolone derivatives as multi-target agents against Alzheimer's disease

In this study, four series of compounds with benzoxazolone and benzothiazolone cores were designed, synthesized and evaluated as multifunctional agents against Alzheimer's disease (AD). Additionally, in order to shed light on the effect of the carbonyl groups of benzoxazolone/benzothiazolone, benzoxazole/benzothiazole-containing analogues were also synthesized and evaluated. Inhibition potency of all final compounds towards cholinesterase enzymes and their antioxidant activity were tested. Subsequently, the anti-inflammatory activity, cytotoxicity, apoptosis, and Aβ aggregation inhibition tests were also performed for selected compounds. The results indicated that compounds 11c, a pentanamide derivative with benzothiazolone core, and 14b, a keton derivative with benzothiazolone core, were considered as promising multi-functional agents for further investigation against AD. The reversibility, kinetic and molecular docking studies were also performed for the compounds with the highest AChE 14b (eeAChE IC50 = 0.34 μM, huAChE IC50 = 0.46 μM) and BChE 11c (eqBChE IC50 = 2.98 μM, huBChE IC50 = 2.56 μM) inhibitory activities.

Novel hydrazone derivatives comprising aryl or heteroaryl group substituted at terminal amine and use thereof

The present invention relates to novel hydrazone derivatives with an aryl or heteroaryl group substituted at a terminal amine group thereof and a use thereof.

Experimental and theoretical investigation of the intramolecular cyclisation of N-(benzoxazolinon-6-Yl) Maleimide derivatives

A new N-H and N-CH3 2(3H)-benzoxazolones substituted at the C6 position in the aromatic ring by imide group (maleimides) has been synthesized in good yields. The regioselectivity of the cyclisation step has been investigated through DFT calculations at the B3LYP/6-31G (d,p) level of theory. The obtained results indicate that the maleimide is favored both kinetically and thermodynamically as observed experimentally.