99595-73-0 Usage
Description
1-(4-aminophenyl)-1H-tetrazol-5(4H)-one, also known as 4-Amino-1-phenyl-1H-tetrazol-5(4H)-one or Anilinoazotetrazole, is a chemical compound belonging to the tetrazole derivative class. It features a five-membered aromatic ring composed of four nitrogen atoms and one carbon atom, with an additional amino group attached to the phenyl ring. 1-(4-aminophenyl)-1H-tetrazol-5(4H)-one has a molecular formula of C7H7N5O and holds potential in various applications, particularly in the pharmaceutical industry.
Uses
Used in Pharmaceutical Industry:
1-(4-aminophenyl)-1H-tetrazol-5(4H)-one is used as a precursor for the synthesis of other organic compounds and pharmaceutical drugs. Its unique structure allows for the development of new molecules with potential therapeutic applications.
Used in Organic Chemistry:
In the field of organic chemistry, 1-(4-aminophenyl)-1H-tetrazol-5(4H)-one serves as a reagent for the synthesis of various heterocyclic compounds. Its versatility in chemical reactions makes it a valuable component in the creation of complex molecular structures.
Used in Research and Development:
Due to its potential pharmacological properties, 1-(4-aminophenyl)-1H-tetrazol-5(4H)-one is utilized in research and development for further exploration of its possible uses and effects. This may include studies on its interaction with biological systems and its potential as a therapeutic agent.
Check Digit Verification of cas no
The CAS Registry Mumber 99595-73-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 9,9,5,9 and 5 respectively; the second part has 2 digits, 7 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 99595-73:
(7*9)+(6*9)+(5*5)+(4*9)+(3*5)+(2*7)+(1*3)=210
210 % 10 = 0
So 99595-73-0 is a valid CAS Registry Number.
99595-73-0Relevant articles and documents
An optimised series of substituted N-phenylpyrrolamides as DNA gyrase B inhibitors
Tiz, Davide Benedetto,Skok, ?iga,Durcik, Martina,Toma?i?, Tihomir,Ma?i?, Lucija Peterlin,Ila?, Janez,Zega, Anamarija,Draskovits, Gábor,Révész, Tamás,Nyerges, ákos,Pál, Csaba,Cruz, Cristina D.,Tammela, P?ivi,?igon, Du?an,Kikelj, Danijel,Zidar, Nace
, p. 269 - 290 (2019)
ATP competitive inhibitors of DNA gyrase and topoisomerase IV have great therapeutic potential, but none of the described synthetic compounds has so far reached the market. To optimise the activities and physicochemical properties of our previously reported N-phenylpyrrolamide inhibitors, we have synthesized an improved, chemically variegated selection of compounds and evaluated them against DNA gyrase and topoisomerase IV enzymes, and against selected Gram-positive and Gram-negative bacteria. The most potent compound displayed IC50 values of 6.9 nM against Escherichia coli DNA gyrase and 960 nM against Staphylococcus aureus topoisomerase IV. Several compounds displayed minimum inhibitory concentrations (MICs) against Gram-positive strains in the 1–50 μM range, one of which inhibited the growth of Enterococcus faecalis, Enterococcus faecium, S. aureus and Streptococcus pyogenes with MIC values of 1.56 μM, 1.56 μM, 0.78 μM and 0.72 μM, respectively. This compound has been investigated further on methicillin-resistant S. aureus (MRSA) and on ciprofloxacin non-susceptible and extremely drug resistant strain of S. aureus (MRSA VISA). It exhibited the MIC value of 2.5 μM on both strains, and MIC value of 32 μM against MRSA in the presence of inactivated human blood serum. Further studies are needed to confirm its mode of action.
