99651-65-7

Usage

Uses

1,2-Propanediol, 3-(dodecyloxy)-, (S)is used in the preparation of lysophosphatidylcholine (LPC) analogs for studying the structure-activity relationships of autotaxin. Autotaxin is an enzyme involved in the regulation of cell motility and is implicated in various diseases, including cancer and inflammatory disorders. The LPC analogs prepared using 1-O-Dodecyl-sn-glycerol can help researchers understand the role of autotaxin in these diseases and develop potential therapeutic agents.
Used in Pharmaceutical Industry:
1,2-Propanediol, 3-(dodecyloxy)-, (S)is used to prepare cysteine-based lipopeptides as Toll-like receptor 2 (TLR2) agonists. TLR2 is a receptor involved in the innate immune system and plays a crucial role in the recognition of pathogens and the activation of immune responses. Cysteine-based lipopeptides prepared using 1-O-Dodecyl-sn-glycerol can act as TLR2 agonists, stimulating the immune system and potentially serving as adjuvants in vaccines or therapeutic agents for infectious diseases and immune disorders.

Upstream product

• 91423-46-0 (S)-3-(dodeca-1,3,5,7,9-pentaenyloxy)propane-1,2-diol 
• 1731-88-0 methyl tridecanoate 
• 112-53-8 1-dodecyl alcohol 
• 51323-71-8 dodecyl mesylate 
• 60456-23-7 (S)-oxiranemethanol 
• 143-15-7 1-dodecylbromide 
• 14347-78-5 1,2-O-isopropylidene-D-glycerol 

Downstream Products

• 1305349-90-9 (R)-1-dodecyl-3-trityl-glycerol 
• 99651-71-5 (R)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (R)-1-dodecyloxymethyl-2-((R)-3,3,3-trifluoro-2-methoxy-2-phenyl-propionyloxy)-ethyl ester 

Relevant academic research and scientific papers

Enantiomeric synthesis of natural alkylglycerols and their antibacterial and antibiofilm activities

Alkylglycerols (AKGs) are bioactive natural compounds that vary by alkyl chain length and degree of unsaturation, and their absolute configuration is 2S. Three AKGs (5l–5n) were synthesised in enantiomerically pure form, and were characterised for the first time together with 12 other known and naturally occurring AKGs (5a–5k, 5o). Their structures were established using 1H and 13C APT NMR with 2D-NMR, ESI-MS or HRESI-MS and optical rotation data, and they were tested for their antibacterial and antibiofilm activities. AKGs 5a–5m and 5o showed activity against five clinical isolates and P. aeruginosa ATCC 15442, with MIC values in the range of 15–125 μg/mL. In addition, at half of the MIC, most of the AKGs reduced S. aureus biofilm formation in the range of 23%–99% and P. aeruginosa ATCC 15442 biofilm formation in the range of 14%–64%. The antibiofilm activity of the AKGs assessed in this work had not previously been studied.

OXIDIZED LIPID COMPOUNDS AND USES THEREOF

Novel oxidized lipids are provided herein, as well as methods for producing same, and uses thereof in treating or preventing an inflammation associated with endogenous oxidized lipids and related conditions.

Autotaxin structure-activity relationships revealed through lysophosphatidylcholine analogs

Autotaxin (ATX) catalyzes the hydrolysis of lysophosphatidylcholine (LPC) to form the bioactive lipid lysophosphatidic acid (LPA). LPA stimulates cell proliferation, cell survival, and cell migration and is involved in obesity, rheumatoid arthritis, neuropathic pain, atherosclerosis and various cancers, suggesting that ATX inhibitors have broad therapeutic potential. Product feedback inhibition of ATX by LPA has stimulated structure-activity studies focused on LPA analogs. However, LPA displays mixed mode inhibition, indicating that it can bind to both the enzyme and the enzyme-substrate complex. This suggests that LPA may not interact solely with the catalytic site. In this report we have prepared LPC analogs to help map out substrate structure-activity relationships. The structural variances include length and unsaturation of the fatty tail, choline and polar linker presence, acyl versus ether linkage of the hydrocarbon chain, and methylene and nitrogen replacement of the choline oxygen. All LPC analogs were assayed in competition with the synthetic substrate, FS-3, to show the preference ATX has for each alteration. Choline presence and methylene replacement of the choline oxygen were detrimental to ATX recognition. These findings provide insights into the structure of the enzyme in the vicinity of the catalytic site as well as suggesting that ATX produces rate enhancement, at least in part, by substrate destabilization.

New acetylenic enol ethers of glycerol from the sponge petrosia sp

Ten acetylenic enol ethers of glycerols, including six new compounds (1- 6) and a linear acetylenic alcohol (7), have been isolated from a sponge of the genus Petrosia. The structures of the novel compounds were elucidated by spectroscopic methods. The absolute stereochemistry of 1-7 was determined by chemical transformations and the Mosher method. Some of these compounds exhibited weak cytotoxicity against a human leukemia cell-line (K-562).