99682-51-6Relevant academic research and scientific papers
Direct C2-arylation ofN-acyl pyrroles with aryl halides under palladium catalysis
Chen, Weiqiang,Li, Hui-Jing,Cheng, Yun-Fei,Wu, Yan-Chao
, p. 1555 - 1564 (2021)
C2-arylation ofN-acyl pyrroles with aryl halides is developed for the first time using Pd(PPh3)4as a catalyst in combination with Ag2CO3under air, which allowed the application of a good compatibility catalytic system. This protocol provides a straightforward method for the preparation of valuable arylated pyrroles in moderate to good yields under the standard conditions with good substrate tolerance. Interestingly, whileN-benzoyl pyrroles reacted well, the use of substrates with a thiophene or furan ring indicated that the thiophene and furan rings are more reactive than pyrrole for the present catalytic system.
Autotandem catalysis: Synthesis of pyrroles by gold-catalyzed cascade reaction
Ueda, Hirofumi,Yamaguchi, Minami,Kameya, Hiroshi,Sugimoto, Kenji,Tokuyama, Hidetoshi
supporting information, p. 4948 - 4951 (2015/04/27)
A novel synthesis of substituted pyrroles by a gold(I)-catalyzed cascade reaction has been developed. The reaction proceeded with an autotandem catalysis consisting of an initial addition of gold-acetylide to an acetal moiety and was followed by gold-catalyzed 5-endo-dig cyclization and aromatization. Gold catalysts play a dual role in activating nucleophilicity or electrophilicity of terminal acetylenes by forming gold-acetylides or by π-coordination. The formal (3 + 2) annulation of two components provided a variety of substituted pyrroles in a modular fashion.
SYNTHESE DE PYRROLES ET D'OXAZOLES PAR PYROLYSE DE N-(HYDROXY-2' ETHYL) AMINO-3 PROPENOATE
Pale-Grosdemange, Catherine,Chuche, Josselin
, p. 3397 - 3414 (2007/10/02)
The gas phas pyrolysis of various N-(2'-hydroxyethyl)-3-amino propenoates 1-6 and N-(2'-hydroxy-2'-phenyl ethyl)-3-amino propanoate 7-9 at 390 deg C-420 deg C leads respectively to formylpyrroles 11-16 and benzoylpyrroles 17-19 and, in some cases, to substituted oxazoles 36-39.The results are best explained by the intermediate formation of a dicarbonyl derivative followed either by an intramolecular thermal crotonisation or a six ? electrocyclization of an azomethine ylide.
HEXACARBONYLMOLYBDENUM- OR NONACARBONYLDIIRON-INDUCED REACTION OF 1,3-OXAZEPINE RING SYSTEM. EVIDENCE FOR THE VALENCE ISOMERIZATION BETWEEN 1,3-OXAZEPINE AND PYRIDINE-2,3-OXIDE
Nitta, Makoto,Kobayashi, Tomoshige
, p. 877 - 880 (2007/10/02)
Upon treatment with or , phenyl-substituted 1,3-oxazepines undergo the C-2-O and C-7-O bond cleavage to give pyridine and pyrrole derivatives via a coordinated pyridine-2,3-oxide.
