99702-70-2

Upstream product

• 99702-69-9 3-Ethoxycarbonylmethyl-2,5-dioxo-4,4-diphenyl-imidazolidine-1-carboxylic acid ethyl ester 
• 57-41-0 phenythoin 
• 105-36-2 ethyl bromoacetate 
• 105-39-5 chloroacetic acid ethyl ester 

Downstream Products

• 23780-54-3 5,5-diphenyl-1-hydantoinacetic acid 
• 1413432-65-1 2-(2,4-dioxo-5,5-diphenylimidazolidin-1-yl)acetohydrazide 
• 1413432-80-0 N'-(4-chlorobenzylidene)-2-(2,4-dioxo-5,5-diphenylimidazolidin-1-yl)acetohydrazide 
• 1413432-70-8 C₂₃H₂₆N₄O₈ 
• 1413432-71-9 C₃₀H₃₂N₄O₁₁ 
• 1413432-72-0 C₃₀H₃₂N₄O₁₁ 
• 1413432-73-1 C₃₃H₃₆N₄O₁₃ 
• 1413432-74-2 C₃₃H₃₆N₄O₁₃ 
• 1413432-75-3 C₃₂H₃₄N₄O₁₂ 
• 1413432-76-4 C₃₂H₃₄N₄O₁₂ 

Relevant academic research and scientific papers

Synthesis, anti-inflammatory, analgesic and COX-1/2 inhibition activities of anilides based on 5,5-diphenylimidazolidine-2,4-dione scaffold: Molecular docking studies

The design, synthesis and pharmacological activities of a group of 5,5-diphenylimidazolidine-2,4-dione bearing anilide, phenacyl and benzylidene fragments 2-27 were reported. The prepared 5,5-diphenylimidazolidine-2,4-dione derivatives were evaluated in vivo for anti-inflammatory, analgesic activities and in vitro for COX-1/2 inhibition assay. Among the tested compounds, derivatives 5, 9, 10, 13, and 14 showed significant and potent anti-inflammatory and analgesic activities almost equivalent to reference drug celecoxib. In COX-1/2 inhibition assay, compounds 5, 9, 10 and 14 showed high COX-2 inhibitory activity (IC50 = 0.70 μM, 0.44 μM, 0.61 μM and 0.41 μM; respectively) and selectivity index (SI) range of 142-243 comparable to celecoxib [COX-2 (SI) > 333]. These potent COX-2 inhibitors 9, 10, 13, and 14 were docked into the active site pocket of COX-2 to explore the binding mode and possible interactions of these ligands.

Synthesis and antimicrobial activity of new phenytoin derivatives and their acyclic nucleoside analogs

New phenytoin derivatives and their N-substituted acyclic nucleoside analogs were prepared. The synthesized compounds were tested for their antimicrobial activity against Escherichia coli, Staphylococcus aureus, and Streptomyces Sp. Most of the tested compounds exhibited moderate to high antimicrobial activity while a few compounds were found to exhibit little or no activity against the tested microorganisms.

Antimicrobial activity of new synthesized [(oxadiazolyl)methyl]phenytoin derivatives

A number of substituted phenytoin derivatives in addition to their sugar hydrazones were newly synthesized. Furthermore, the corresponding derived 1,3,4-oxadiazole and their thioglycoside as well as their acyclic analogs were prepared. The antimicrobial activity of the prepared compounds was evaluated against Escherichia coli, Bacillus subtilis, Staphylococcus aureus, Aspergillus niger and Candida albicans. The dithiohydrazone as well as oxadiazole thiole derivatives, sugar hydrazones and acyclic nucleoside analogs were the highly active compounds.

SOME EXAMPLES OF 5,5-DIPHENYLHYDANTOIN ALKYLATION

The method of N1 and N3 alkylation of 5,5-diphenylhydantoin has been described for some examples.The synthesis of only N1 alkylated compound 11 has been accomplished with ethoxycarbonyl as the N3 protecting grou