99708-49-3

Usage

Uses

Used in Organic Synthesis:
3-(6-chloropyridazin-3-yl)benzonitrile is used as a key intermediate in organic synthesis for the creation of various complex organic molecules. Its unique structure allows for versatile chemical reactions, facilitating the synthesis of a wide range of compounds.
Used in Pharmaceutical Research:
In the pharmaceutical industry, 3-(6-chloropyridazin-3-yl)benzonitrile is utilized as a building block for the synthesis of biologically active molecules. Its incorporation into drug candidates can potentially lead to the development of new therapeutic agents with novel mechanisms of action.
Used in Research and Development:
3-(6-chloropyridazin-3-yl)benzonitrile is employed in research and development settings to explore its potential biological activities and therapeutic properties. Further studies are required to understand its full potential and to determine its suitability for various applications in the medical and chemical fields.

Upstream product

• 135034-10-5 3-chloro-6-iodopyridazine 
• 150255-96-2 (3‐cyanophenyl)boronic acid 

Downstream Products

• 1201930-22-4 3-[3-(3-bromobenzyl)-1,2,4-triazolo[4,3-b]pyridazin-6-yl]benzonitrile 
• 1233361-02-8 (2S,4S)-4-(2-{3-[3-(3-cyanophenyl)-6-oxo-6H-pyridazin-1-yl-methyl]phenyl}pyrimidin-5-yloxy)pyrrolidine-2-carboxylic acid 
• 1103506-77-9 3-{1-[3-(5-bromopyrimidin-2-yl)-benzyl]-6-oxo-1,6-dihydro-pyridazin-3-yl}-benzonitrile 
• 1103506-79-1 3-{1-[3-(5-hydroxy-pyrimidin-2-yl)-benzyl]-6-oxo-1,6-dihydro-pyridazin-3-yl}-benzonitrile 
• 1103508-21-9 3-(6-oxo-1-{3-[5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-pyrimidin-2-yl]-benzyl}-1,6-dihydropyridazin-3-yl)-benzonitrile 
• 52240-08-1 3-(6-oxo-1,6-dihydropyridazin-3-yl)-benzonitrile 
• 93182-14-0 3-(4-hydroxypiperidino)-6-(3-cyanophenyl)pyridazine 

Relevant academic research and scientific papers

Novel Triazolo Pyridazine Derivatives and Use Thereof

The present invention relates to a novel triazolo pyridazine derivative or a pharmaceutically acceptable salt thereof, to a pharmaceutical composition for inhibiting c-Met tyrosine kinase activity and a pharmaceutical composition for preventing or treating an abnormal proliferation disorder (hyperproliferative disorder) comprising same as an active ingredient, and to a method for preventing or treating an abnormal proliferation disorder (hyperproliferative disorder) comprising a step of administering a pharmaceutically effective amount of the pharmaceutical composition to a subject in need thereof. The present invention can advantageously be used as a therapeutic agent for various abnormal proliferation disorders such as cancer, psoriasis, rheumatoid arthritis and diabetic retinopathy which are associated with excessive cell proliferation and growth due to irregular kinase activity by effectively suppressing the activity of c-Met tyrosine kinase.

3-(3-PYRIMIDIN-2-YLBENZYL)-1,2,4-TRIAZOLO[4,3-B]PYRIDAZINE DERIVATIVES AS MET KINASE INHIBITORS

Compounds of the formula (I), in which R1, R2, R3, R3′, R4 have the meanings indicated in Claim 1, are inhibitors of tyrosine kinases, in particular of Met kinase, and can be employed, inter alia, for the treatment of tumours.

PYRIDAZINONE DERIVATIVES

Compounds of the formula (I), in which Y, R1, R2, R3 and R3′ have the meanings indicated in claim 1, are inhibitors of tyrosine kinases, in particular of Met kinase, and can be employed, inter alia, for the treatment of tumours.