135034-10-5

Usage

Uses

Used in Pharmaceutical Industry:
3-Chloro-6-iodopyridazine is used as a reactant in the Suzuki-Miyaura coupling reaction for the synthesis of complex organic molecules, particularly in the development of new pharmaceutical compounds. The Suzuki-Miyaura coupling is a widely used method for the formation of carbon-carbon bonds, which is essential in the creation of diverse molecular structures with potential therapeutic applications.
Used in Chemical Synthesis:
3-Chloro-6-iodopyridazine is used as a reactant in the synthesis of 6-Chloropyridazine-3-carbonitrile (C368635), which is an important intermediate in the production of various chemical compounds. The carbonitrile group in 6-Chloropyridazine-3-carbonitrile can be further functionalized or used as a building block for the development of new molecules with specific properties and applications.

InChI:InChI=1/C4H2ClIN2/c5-3-1-2-4(6)8-7-3/h1-2H

Upstream product

• 141-30-0 3,6-dichlorpyridazine 
• 1120-95-2 3-chloropyridazine 
• 17973-86-3 3,6-dibromopyridazine 

Downstream Products

• 28657-41-2 3-chloro-6-(2'-thienyl)pyridazine 
• 258506-68-2 3-chloro-6-(trifluormethyl)pyridazine 
• 77778-15-5 3-chloro-6-(2-phenylethynyl)pyridazine 
• 20375-65-9 3-chloro-6-phenylpyradazine 
• 78784-66-4 3-chloro-6-(pyridin-3-yl)pyridazine 
• 927673-83-4 3-chloro-6-(2,3-dichlorophenyl)pyridazine 
• 35857-89-7 6-chloropyridazine-3-carbonitrile 
• 943541-20-6 3-chloro-6-(1-methyl-1H-pyrazol-4-yl)pyridazine 
• 1159251-67-8 (6-iodo-pyridazine-3-yl)-(5-methyl-3-phenyl-isoxazol-4ylmethyl)-amine 
• 1159251-03-2 3-Iodo-6-(5-methyl-3-phenyl-isoxazol-4-ylmethoxy)-pyridazine 
• 1192799-66-8 3-chloro-6-(3,5-dibromo-4-methoxyphenyl)pyridazine 
• 1192799-53-3 2,6-dichloro-4-(6-(ethyl(3-fluorobenzyl)amino)pyridazin-3-yl)phenol 
• 1192799-71-5 C₁₃H₁₃ClFN₃ 
• 1192799-70-4 C₁₃H₁₃FIN₃ 

Relevant academic research and scientific papers

Desymmetrization of dichloroazaheterocycles

3,6-Dichloropyridizine 1a was converted in good yield into its mono-iodo derivative 1b when treated with a mixture of hydriodic acid and sodium iodide. Pure samples of the mono-iodo derivatives 2b, 3b and 4b could not be obtained from their corresponding dichlorinated precursors with these reagents. Compounds 1b and 4b underwent palladium catalysed Suzuki, Sonogashira and other coupling reactions.

Synthesis and evaluation of 3-amino-6-aryl-pyridazines as selective CB2 agonists for the treatment of inflammatory pain

A series of 3-amino-6-aryl-pyridazines have been identified as CB2 agonists with high efficacy and selectivity against the CB1 receptor. Details of the investigation of structure-activity relationships (SAR) are disclosed, which led to the identification of pyridazine analogue 35, a compound with high potency in an in vivo model of inflammatory pain.

COMPOUNDS AND COMPOSITIONS FOR USE IN TREATING SKIN DISORDERS

Provided herein is a compound of formula (XXXII) or a pharmaceutically acceptable salt, solvate, hydrate, stereoisomer thereof or a physiologically functional derivative thereof, wherein R1, R2, R3, G, A, E, n, p, and q are defined herein. Also provided herein are compositions comprising a compound of formula (XXXII), and methods of using a compound of formula (XXXII), e.g., in the treatment or prevention of skin disorders.

PESTICIDALLY ACTIVE TETRACYCLIC HETEROCYCLIC DERIVATIVES WITH SULPHUR CONTAINING SUBSTITUENTS

Compounds of formula (I), wherein the substituents are as defined in claim 1, and the agrochemically acceptable salts salts, stereoisomers, enantiomers, tautomers and N-oxides of those compounds, can be used as insecticides and can be prepared in a manner known per se.

PESTICIDALLY ACTIVE POLYCYCLIC DERIVATIVES WITH SULFUR SUBSTITUTED FIVE-MEMBERED RING HETEROCYLES

Polycyclic derivatives of formula (I) wherein the substituents are as defined in claim 1, and the agrochemically acceptable salts, stereoisomers, enantiomers, tautomers and N-oxides of those compounds, can be used as insecticides and can be prepared in a manner known per se.

PESTICIDALLY ACTIVE POLYCYCLIC DERIVATIVES WITH SULFUR CONTAINING SUBSTITUENTS

Polycyclic derivatives of formula (I), wherein the substituents are as defined in claim 1, and the agrochemically acceptable salts salts, stereoisomers, enantiomers, tautomers and N-oxides of those compounds, can be used as insecticides and can be prepared in a manner known per se.

NOVEL TRIFLUOROMETHYL-OXADIAZOLE DERIVATIVES AND THEIR USE IN THE TREATMENT OF DISEASE

The invention relates to novel trifluoromethyl-oxadiazole derivatives of formula (I), and pharmaceutically acceptable salts thereof, in which all of the variables are as defined in the specification, pharmaceutical compositions thereof, pharmaceutical com

Copper-mediated trifluoromethylation of heteroaromatic compounds by trifluoromethyl sulfonium salts

Copper is king! A convenient method for the synthesis of trifluoromethylated heteroaromatic compounds under mild conditions has been developed based on the observation that 1 can be reduced by certain metals (see scheme). Substrate 1 is assumed to be reduced by copper via a single-electron transfer mechanism, and CuCF3 is the most probable intermediate in this reaction. DMF=N,N-dimethylformamide, Tf=triflate.

THERAPEUTIC COMPOUNDS

The invention provides compounds of formula I or a salt thereof as described herein. The invention also provides pharmaceutical compositions comprising a compound of formula I, processes for preparing compounds of formula I, intermediates useful for prepa

Heteroatom-substituted analogues of orphan nuclear receptor small heterodimer partner ligand and apoptosis inducer (E)-4-[3-(1-adamantyl)-4- hydroxyphenyl]-3-chlorocinnamic acid

(E)-4-[3'-(1-Adamantyl)-4'-hydroxyphenyl]-3-chlorocinnamic acid (3-Cl-AHPC) induces the cell cycle arrest and apoptosis of cancer cells. Because its pharmacologic properties-solubility, bioavailability, and toxicity-required improvement for translation, s