99712-22-8Relevant academic research and scientific papers
A CONVENIENT PROCEDURE FOR THE PREPARATION OF DINUCLEOSIDE PHOSPHATES BY THE USE OF A BIFUNCTIONAL PHOSPHORYLATING REAGENTS, 2-CHLOROPHENYLPHOSPHOROBIS(NITROBENZOTRIAZOLIDE)
Mitsunobu, Oyo,Takahashi, Miyako,Seki, Hiroshi,Arai, Makoto,Yasumoto, Fumiko,et al.
, p. 949 - 952 (2007/10/02)
The reagent formed by the reaction of 2-chlorophenyl phosphorodichloridate with 2 molar amounts of 5-nitrobenzotriazole was allowed to react successively with nucleosides having free 3'-hydroxyl groups and nucleosides having free 5'-hydroxyl groups affording the corresponding dinucleoside phosphates in 63-97 percent yields.
