99758-64-2

Upstream product

• 17610-00-3 3,5-Di-tert-butylbenzaldehyde 
• 557-21-1 dicyanozinc 
• 22385-77-9 1-bromo-3,5-di-tert-butylbenzene 

Downstream Products

• 107680-82-0 3,6-bis-(3,5-di-tert-butylphenyl)-2,5-dihydropyrrolo<3,4-c>pyrrole-1,4-dione 
• 349546-86-7 5-(3,5-bis-tert-butylphenyl)tetrazole 
• 139693-30-4 (3,5-di-tert-butyl)benzylamine 
• 107711-05-7 3,6-Bis(3,5-di-tert-butylphenyl)-2,5-dihydro-2,5-dimethylpyrrolo<3,4-c>pyrrol-1,4-dion 
• 349546-87-8 C₃₉H₄₈N₄O₃ 
• 349546-89-0 3,5-bis-[5-(3,5-di-tert-butyl-phenyl)-[1,3,4]oxadiazol-2-yl]-phenol 
• 17610-02-5 1-(3,5-di-tert-butyl-phenyl)-propan-1-one 
• 1756-31-6 1-(3,5-di-tert-butylphenyl)ethanone 

Relevant academic research and scientific papers

A new oxazole ligand for the copper-catalyzed cyanation of aryl halides with K4 [Fe(CN)6]

An efficient and new method for the copper-catalyzed cyanation of aryl halides is reported using a new oxazole ligand and K4Fe(CN) 6 as a non-toxic source of cyanide.

Efficient copper-catalyzed cyanation of aryl bromides using 1,3-phenylene-bis-(1h)-tetrazole as an efficient ligand

A new method for the synthesis of aryl nitriles has been developed by the cyanation of aryl bromides with K4Fe(CN)6 as a cyanide source in the presence of Cu(OAc)2.H2O as an inexpensive catalyst and a 1,3-phenylene-bis-(1H)-tetrazole ligand. This method has the advantages of high yield, simple methodology and easy work-up.

Copper iodide nanoparticles-catalysed cyanation of aryl halides using non-toxic K4[Fe(CN)6] in the presence of 1,2-bis(5-tetrazolyl)benzene as an efficient ligand

Cyanation of aryl bromides were carried out with K4[Fe(CN) 6] in the presence of catalytic amounts of a copper salt and 1,2-bis(5-tetrazolyl)benzene as a ligand under thermal conditions. This method has the advantages of high yields, simple methodology and easy work up.

The Pd(0) nanoparticles stabilized by collagen fibers as a recyclable heterogeneous catalyst for the cyanation of aryl bromides using k4fe(cn)6 as non-toxic source of cyanide

A new method for the synthesis of aryl nitriles has been developed by the cyanation of aryl bromides in the presence of the Pd(0) nanoparticles stabilized by collagen fibers as a highly active, air-stable and recyclable heterogeneous catalyst. This method has the advantages of high yields, simple methodology and easy work-up. The catalyst was recovered and reused several times without the significant loss of its catalytic performance.

Efficient cyanation of aryl bromides with K4[Fe(CN)6] catalyzed by a palladium-indolylphosphine complex

This study describes a general palladium-catalyzed cyanation of aryl bromides using K4[Fe(CN)6] as the cyanide surrogate. The reactions can be successfully conducted under mild reaction conditions (at 50 °C) in mixed solvents (water/MeCN = 1:1) without any surfactant additives, and afford the desired aryl nitriles in good-to-excellent yields. Particularly noteworthy is that this system allows the mildest reaction temperature reported so far for palladium-catalyzed cyanation of aryl bromides with K 4[Fe(CN)6] source in general. Common functional groups, including keto, aldehyde, free amine, and heterocyclic substrates are compatible under this system. Interestingly, the phosphine ligands bearing -PCy 2 moiety, which usually show excellent activity in aryl halide couplings, are found less effective than the corresponding ligands with -PPh2 group.

Application of polymer-supported triphenylphosphine and microwave irradiation to the palladium-catalyzed cyanation of aryl triflates

A variety of aryl nitriles were prepared in excellent yield from the palladium(II) acetate-catalyzed cross-coupling of aryl triflates and zinc cyanide under microwave irradiation conditions. To facilitate purification, polymer-supported triphenylphosphine was used as the palladium ligand. Comparison to the corresponding thermal conditions revealed much shorter reaction times with comparable yields. Copyright Taylor & Francis Group, LLC.

2-AMINO- AND 2-THIO-SUBSTITUTED 1,3-DIAMINOPROPANES

Disclosed are compounds of the formula: where variables Q, Z, X, R15, R2, R3, and Rc are defined herein. Compounds disclosed herein are inhibitors of the beta-secretase enzyme and are therefore useful in the treatment of Alzheimer’s disease and other diseases characterized by deposition of A beta peptide in a mammal.