1756-31-6Relevant articles and documents
Chemical Consequences of the Mechanical Bond: A Tandem Active Template-Rearrangement Reaction
Modicom, Florian,Jamieson, Ellen M. G.,Rochette, Elise,Goldup, Stephen M.
supporting information, p. 3875 - 3879 (2019/02/24)
We report the unexpected discovery of a tandem active template CuAAC-rearrangement process, in which N2 is extruded on the way to the 1,2,3-triazole product to give instead acrylamide rotaxanes. Mechanistic investigations suggest this process i
Tropylium Ion Catalyzes Hydration Reactions of Alkynes
Oss, Giulia,Ho, Junming,Nguyen, Thanh Vinh
supporting information, p. 3974 - 3981 (2018/08/17)
The hydration of alkynes is one of the most atom-economic and versatile synthetic protocols to access carbonyl compounds. This fundamental reaction, however, often requires transition-metal catalysts or harsh reaction conditions to promote the addition of water to the carbon–carbon triple bond. In this work, it is demonstrated that the non-benzenoid aromatic tropylium ion can be used as an organic Lewis acid promoter for the hydration of alkynes under simple reaction conditions with excellent outcomes.
Design, synthesis and biological evaluation of nuclear receptor-degradation inducers
Itoh, Yukihiro,Kitaguchi, Risa,Ishikawa, Minoru,Naito, Mikihiko,Hashimoto, Yuichi
experimental part, p. 6768 - 6778 (2012/01/13)
Compounds that regulate the function(s) of nuclear receptors (NRs) are useful for biological studies and as candidate therapeutic agents. Most such compounds are agonists or antagonists. On the other hand, we have developed specific protein degradation in
