99769-28-5

Basic information

• Product Name: 1-BroMo-4-Methanesulfonyl-2-Methylbenzene
• Synonyms: 1-BroMo-4-Methanesulfonyl-2-Methylbenzene;1-Bromo-2-methyl-4-(methylsulfonyl)benzene
• CAS NO: 99769-28-5
• Molecular Formula: C₈H₉BrO₂S
• Molecular Weight: 249.12486
• Mol File: 99769-28-5.mol
• Article Data: 8

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-BroMo-4-Methanesulfonyl-2-Methylbenzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1-BroMo-4-Methanesulfonyl-2-Methylbenzene(99769-28-5)
• EPA Substance Registry System: 1-BroMo-4-Methanesulfonyl-2-Methylbenzene(99769-28-5)

Safety Data

• Hazardous Substances Data: 99769-28-5(Hazardous Substances Data)

Usage

Synonyms

1-bromo-4-(methanesulfonyl)-2-methylbenzene

Physical state

Colorless to pale yellow liquid

Molecular weight

249.127 g/mol

Pharmaceutical industry

Intermediate for the synthesis of various pharmaceutical products

Specialty chemicals

Building block in the synthesis of specialty chemicals and other organic compounds

Hazardous nature

Considered a hazardous chemical

Safety precautions

Should be handled and stored with proper safety precautions

Upstream product

• 108-40-7 toluene-3-thiol 
• 4886-77-5 3-methylthioanisole 
• 90532-02-8 1-bromo-2-methyl-4-methylsulfanylbenzene 

Downstream Products

• 1610372-71-8 2-(5-(2-(isopropylamino)ethoxy)-6-(2-methyl-4-(methylsulfonyl)phenyl)pyridin-2-yl)-5,7-dimethoxyquinazolin-4(3H)-one 
• 1610373-51-7 2-[5-(2-bromo-ethoxy)-6-(4-methanesulfonyl-2-methyl-phenyl)-pyridin-2-yl]-5,7-dimethoxy-3H-quinazolin-4-one 
• 1610372-65-0 2-(5-(2-hydroxyethoxy)-6-(2-methyl-4-(methylsulfonyl)phenyl)pyridin-2-yl)-5,7-dimethoxyquinazolin-4(3H)-one 
• 1610373-36-8 5-(2-((tert-butyldimethylsilyl)oxy)ethoxy)-6-(2-methyl-4-(methylsulfonyl)phenyl)picolinaldehyde 
• 1011459-26-9 4,4,5,5-tetramethyl-2-(2-methyl-4-(methylsulfonyl)phenyl)-1,3,2-dioxaborolane 

Relevant articles and documents

NAPHTHYRIDINE DERIVATIVES AS PRC2 INHIBITORS

Disclosed are compounds of formula (I) or (II) that inhibit Polycomb Repressive Complex 2 (PRC2) activity. In particular, the present invention relates to compounds, pharmaceutical compositions and methods of use, such as methods of treating cancer using the compounds and pharmaceutical compositions of the present invention.

PRC2 INHIBITORS

The present invention relates to compounds that inhibit Polycomb Repressive Complex 2 (PRC2) activity. In particular, the present invention relates to compounds, pharmaceutical compositions and methods of use, such as methods of treating cancer using the compounds and pharmaceutical compositions of the present invention. (Formula (I))

TRIAZOLOPYRIMIDINE COMPOUNDS AND USES THEREOF

A compound of Formula (I), or a pharmaceutically acceptable salt thereof, is provided that has been shown to be useful for treating a PRC2-mediated disease or disorder: wherein R1, R2, R3, R4, R5, and n are as defined herein.