99776-28-0

Usage

InChI:InChI=1/C10H13N5O3/c11-10-13-8-7(9(18)14-10)12-5-15(8)2-1-6(3-16)4-17/h1,5,16-17H,2-4H2,(H3,11,13,14,18)

Upstream product

• 99796-40-4 2-amino-9-<4-(benzyloxy)-3-<(benzyloxy)methyl>-2-butenyl>-6-chloropurine 
• 871231-88-8 3,3'-bis-(t-butyldimethylsilyloxymethyl)-prop-2-enyl bromide 
• 107053-40-7 ethyl 4-(benzyloxy)-3-<(benzyloxy)methyl>-2-butenoate 
• 107053-41-8 4-(benzyloxy)-3-<(benzyloxy)methyl>-2-buten-1-ol 
• 99776-39-3 1-(benzyloxy)-2-<(benzyloxy)methyl>-4-chloro-2-butene 
• 172843-32-2 4-(tert-butyldimethylsilanyloxy)-3-(tert-butyldimethylsilanyloxymethyl)-but-2-en-1-ol 

Relevant academic research and scientific papers

Synthesis and antiviral evaluation of novel open-chain analogues of neplanocin A

Novel acyclic nucleoside analogues were designed and synthesized as open-chain analogues of neplanocin A. The coupling of the allylic bromide with purine bases using cesium carbonate afforded a series of novel acyclic nucleosides. The synthesized compound

GUANINE DERIVATIVE

Antivirally active compounds of the formula STR1 wherein A is STR2 wherein m is 1 or 2, n is 1 or 2, whereby m is 1 when n is 2 and m is 2 when n is 1, R a ' is (CH 2) p OH, NHCONH 2 or COR a ", R a " is hydrogen, hydroxy or amino, p is 1 to 4, R b ' and R b " are independently selected from hydrogen or (CH 2) p OH, with the proviso that at least one of R b ' or R b " is hydrogen; or R b ' and R b " together constitute an additional carbon-carbon bond to form an alkyne; or a physiologically acceptable salt, geometric or optical isomer thereof; pharmaceutical preparations containing the compounds and methods for treatment of virus infections.

Synthesis and Biological Activity of Unsaturated Carboacyclic Purine Nucleoside Analogues

Two new carboacyclic nucleoside analogues, 9-adenine (6) and 9-guanine (5), modeled on the unsaturated carbocyclic nucleoside analogue neplanocin A (2), have been synthesized an