99822-20-5

Upstream product

• 2835-06-5 phenylglycin 
• 19883-41-1 D-phenylglycine methyl ester hydrochloride 
• 875-74-1 (R)-phenylglycine 
• 221050-93-7 D-(-)-α-phenylglycine hydrazide 
• 122-51-0 orthoformic acid triethyl ester 
• 143668-50-2 Amino-phenyl-acetic acid hydrazide 
• 99822-22-7 (Dimethylamino-methyleneamino)-phenyl-acetic acid methyl ester 

Downstream Products

• 99702-43-9 5-phenyl-1,2,4-triazine-6(1H)-one 
• 119017-47-9 6-Methoxy-5-phenyl-[1,2,4]triazine 

Relevant academic research and scientific papers

The reaction of optically active α-aminocarboxylic acid hydrazides with triethyl orthoesters

New derivatives of 2-(1-amino-1-phenylmethyl)-1,3,4-oxadiazole and 1,2,4-triazin-6-one were synthesised in the reactions of optically active α-aminocarboxylic acid hydrazides and triethyl orthoesters in xylene. The electronic and steric effects of substituents at the α position influencing the formation of five- or six-membered products are discussed.

Synthesis of 1,2,4-Triazines, XV. - Synthesis of 1,2,4-Triazin-6(1H)-ones

1,2,4-Triazin-6(1H)-ones 3 have been prepared by cyclization of α-ketoacyl chlorides 15 with amidrazones 14. 4,5-Dihydro-1,2,4-triazin-6(1H)-ones 5 were obtained by cyclization of amino acid hydrazides 10 with orthocarboxylates 11.Key Word: 1,2,4-Triazin-

AMINO ACIDS AS SYNTHONS FOR HETEROCYCLES. FORMATION OF 1,2,4-TRIAZINE DERIVATIVES

Transformation of the amino group of amino acids into an amidine and subsequent treatment with hydrazine leads to 1,2,4-triazine-6(1H)-ones.The method described is a new synthetic approach.Unsaturated amino acids gave imidazol-5-one derivatives after the

Reaction of 1,2,4-Triazines with N-Phenylmaleimide

Diels-Alder addition of N-phenylmaleimide (2) to 1,2,4-triazines (1) occurded across carbons 3 and 6 of the triazines to give 1:1 adducts.After losing nitrogen, they gave dihydropyridines, which underwent a variety of further reactions.Pyridine derivative

Efficient Synthesis of 5-Substituted-4,5-dihydro-1,2,4-triazin-6-ones and 5-Substituted-1,2,4-triazin-6-ones

Treatment of methyl α-(dimethylaminomethyleneamino)carboxylates 1 (from α-amino acids and dimethylformamide dimethylacetal) with hydrazine gives 5-substituted-4,5-dihydro-1,2,4-triazin-6-ones 2, which are smoothly dehydrogenated to 5-substituted-1,2,4-tri