99838-65-0

Upstream product

• 1826-67-1 vinyl magnesium bromide 
• 99838-63-8 (2R)-3-benzyloxy-1,2-epoxypentane 
• 1246769-74-3 2-(((4R,5R)-5-(benzyloxy)hept-1-en-4-yl)oxy)tetrahydro-2H-pyran 

Downstream Products

• 289900-51-2 [(R)-1-((R)-1-Benzyloxy-propyl)-but-3-enyloxy]-acetic acid 
• 289900-52-3 (4S)-4-Benzyl-3-{2-[(1R)-1-((1R)-1-benzyloxypropyl)but-3-enyloxy]acetyl}oxazolidin-2-one 
• 289900-53-4 (4R)-4-Benzyl-3-{2-[(1R)-1-((1R)-1-benzyloxypropyl)but-3-enyloxy]acetyl}oxazolidin-2-one 
• 289900-54-5 (4S)-4-Benzyl-3-{(2R)-2-[(1R)-1-((1R)-1-benzyloxypropyl)but-3-enyloxy]pent-4-enoyl}oxazolidin-2-one 
• 289900-55-6 (4R)-4-Benzyl-3-{(2S)-2-[(1R)-1-((1R)-1-benzyloxypropyl)but-3-enyloxy]pent-4-enoyl}oxazolidin-2-one 
• 1246769-76-5 (((4R,5R)-5-(benzyloxy)hept-1-en-4-yl)oxy)(tert-butyl)diphenylsilane 

Relevant academic research and scientific papers

An approach to lauroxanes by iterative use of Co2(CO) 6-acetylenic complexes. A formal synthesis of (+)-laurencin

A new approach to lauroxanes by a powerful and highly convergent methodology based on iterative use of Co2(CO)6-acetylenic complexes is described. The strategy employs an intermolecular Nicholas reaction to form unsaturated branched linear ethers, a ring closing metathesis to obtain the cobalt complex cyclic ethers, and an isomerization promoted by montmorillonite K-10. A short synthesis of cyclic ethers of seven-, eight-, and nine-membered rings is described. Additionally, the methodology is exemplified by the formal synthesis of (+)-laurencin, a red algae metabolite.

Enantio- and Diastereocontrolled Synthesis of Chiral 1,2-Diol Derivatives from (R)-2,3-Di-O-isopropylideneglyceraldehyde: endo- and exo-Brevicomin

All four possible stereoisomers of the insect pheromone brevicomin have been prepared from (R)-2,3-di-O-isopropylideneglyceraldehyde (1) on stereocontrolled routes with ee more than 98-99percent.