99849-29-3Relevant academic research and scientific papers
Synthesis and structure activity relationships of novel small molecule cathepsin D inhibitors
Dumas, Jacques,Brittelli, David,Chen, Jinshan,Dixon, Brian,Holia, Hatoum-Mokdad,Koenig, Gerhard,Sibley, Robert,Witowsky, James,Wong, Stephen
, p. 2531 - 2536 (2007/10/03)
Cathepsin D, a lysosomal aspartyl protease, has been implicated in the pathology of Alzheimer's disease as well as breast and ovarian cancer. A weakly active cathepsin D inhibitor was identified by high throughput screening. Subsequent optimization led to
