99854-11-2Relevant academic research and scientific papers
Industrial production method of 4-hydroxy-1-indanone
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Paragraph 0010; 0062; 0065-0066, (2021/08/14)
The invention discloses an industrial production method of 4-hydroxy-1-indanone, and relates to the technical field of organic chemistry, the industrial production method comprises the following steps: taking dihydrocoumarin as a raw material, carrying out hydrolysis reaction on the dihydrocoumarin under the catalysis of hydrochloric acid to obtain an intermediate 1, and carrying out cyclization reaction on the intermediate 1 and polyphosphoric acid under the catalysis of strongly acidic resin to obtain the 4-hydroxy-1-indanone. The preparation method disclosed by the invention is short in route, easily available in raw materials, high in yield, moderate in reaction condition, suitable for industrial production, less in three wastes, more environment-friendly, easier to operate and stable in process.
COMPOUNDS AND COMPOSITIONS FOR OCULAR DELIVERY
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Page/Page column 108; 217-219, (2020/05/12)
The present invention provides new prodrags of Sunitinib, Brinzolamide, and Dorzolamide and compositions to treat medical disorders, for example glaucoma, a disorder or abnormality related to an increase in intraocular pressure (TOP), a disorder requiring neuroprotection, age-related macular degeneration, or diabetic retinopathy.
