99858-53-4Relevant academic research and scientific papers
Decoquinate derivatives: A new class of potent antischistosomal agents against Schistosoma japonicum
Wang, Wen-Long,Song, Li-Jun,Hu, Bo-Chun,Miao, Li,Chen, Xiao-Yu,Fan, Wen-Hua,Yin, Xu-Ren,Shen, Shuang,Ding, Zhao-Feng,Yu, Chuan-Xin
, p. 1547 - 1552 (2017/07/17)
Decoquinate (1), an old and inexpensive coccidiostat, exhibited potent antimalarial activity, however, its antischistosomal activity against Schistosoma japonicum has not yet been evaluated. Based on decoquinate, a series of decoquinate derivatives was designed, synthesized, evaluated as a new class of antischistosomal agents against S. japonicum adult worms in vitro. Among them, compound 15 killed 100% of adult S. japonicum in 72?h at the concentration of 10?μmol/L in vitro, exhibited stronger worm-killing activity than PZQ in vitro and could serve as a promising lead compound to develop new antischistosomal agents.
Design of postmetallocene catalytic systems of arylimine type for olefin polymerization: XVI. Synthesis of (N-aryl)salicylaldimines containing pent-4-enyloxy group and their complexes with titanium(IV) dichloride
Oleinik,Oleinik,Zaitsev,Ivanchev
, p. 191 - 199 (2014/04/17)
Reactions of p-(pent-4-enyloxy)aniline with salicylaldehyde containing versatile substituents in the positions 3 and 5 in an open system without solvent at 130°C afforded a series of (N-aryl)salicylaldimines, which with TiCl2(OPr-i)2 formed complexes of titanium(IV) dichloride L2TiCl2.
Soluble polymer synthesis: An improved traceless linker methodology for aliphatic C-H bond formation
Zhao, Xu-Yang,Jung, Kyung Woon,Janda, Kim D.
, p. 977 - 980 (2007/10/03)
A traceless linker was developed on a soluble polymer support. The methodology allows for the facile attachment of molecules possessing an alkyl halide appendage. The coupled molecule can be further functionalized before subsequent cleavage via a two-step oxidation-reduction sequence. This sequence allows for the synthesis of molecules containing no trace of the linker and the formation of a new C-H bond.
