99875-27-1Relevant academic research and scientific papers
Structure-activity analysis of CJ-15,801 analogues that interact with Plasmodium falciparum pantothenate kinase and inhibit parasite proliferation
Spry, Christina,Sewell, Alan L.,Hering, Yuliya,Villa, Mathew V.J.,Weber, Jonas,Hobson, Stephen J.,Harnor, Suzannah J.,Gul, Sheraz,Marquez, Rodolfo,Saliba, Kevin J.
, p. 1139 - 1147 (2017/12/15)
Survival of the human malaria parasite Plasmodium falciparum is dependent on pantothenate (vitamin B5), a precursor of the fundamental enzyme cofactor coenzyme A. CJ-15,801, an enamide analogue of pantothenate isolated from the fungus Seimatosp
An efficient approach to the stereocontrolled synthesis of enamides
Villa, Mathew V. J.,Targett, Sarah M.,Barnes, John C.,Whittingham, William G.,Marquez, Rodolfo
, p. 1631 - 1633 (2008/02/02)
A fast, flexible, and efficient approach for the stereocontrolled synthesis of enamides has been developed starting from lactams and amides through the use of imides. This new approach provides access to enamide systems not easily or currently accessible through other approaches.
Ruthenium Tetroxide Oxidation of N-Alkyllactams
Yoshifuji, Shigeyuki,Arakawa, Yukimi,Nitta, Yoshihiro
, p. 357 - 363 (2007/10/02)
Ruthenium tetroxide (RuO4) oxidation of N-alkyllactams proceeded regioselectively depending on the size of lactam ring, except for the seven-membered ring.Four- and eight-membered N-methyl- and N-ethyllactams were oxidized at the exocyclic α-carbon adjacent to nitrogen to produce the N-acyllactams and NH-lactams, while five- and six-membered lactams underwent endocyclic oxidation to yield the cyclic imides.Oxidation of seven-membered lactams yielded a mixture of products arising from both exocyclic and endocyclic oxidations.These regioselectivities were confirmed in the oxidation of substrates having a tertiary carbon at the oxidation position.Keywords---oxidation; ruthenium tetroxide oxidation; regioselective oxidation; hydroxylation; imide synthesis; N-alkyllactam; N-acyllactams; imide; ruthenium tetroxide; two-phase method
OXIDATION OF ORGANIC NITROGEN COMPOUNDS BY MEANS OF RUTHENIUM TETROXIDE: SELECTIVE PREPARATION OF N-SUBSTITUTED LACTAMS
Tangari, Nicola,Giovine, Maria,Morlacchi, Flaviano,Vetuschi, Claudio
, p. 325 - 328 (2007/10/02)
1-Formyl-, 1-acetyl-, and 1-benzoyl-perhydro-azepines and -azocines are oxidized by RuO4 to the corresponding N-acyllactams; the 1-benzyl analogues also undergo major endocyclic oxidation to 1-benzyllactams.
