99887-44-2Relevant academic research and scientific papers
DRUG DELIVERY SYSTEM INCLUDING DRUG-LOADED PHOSPHATE MICELLE
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Paragraph 0035; 0043-0047, (2019/12/25)
The present invention relates to a drug carrier comprising a drug and a carrier loaded with the drug, wherein the carrier is a micelle composed of a phosphate surfactant. The micelle, consisting of the phosphate surfactant contained in a drug carrier, can selectively release the drug loaded into the micelle by being cleaved by an overexpressed enzyme around a target, thereby significantly reducing drug side effects in vivo compared to the prior art, while maximizing a therapeutic effect.COPYRIGHT KIPO 2020
PARTICLE INCLUDING UCNPs-LOADED PHOSPHATE MICELLE AND BEING USED FOR BIOIMAGING
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Paragraph 0050-0051, (2018/09/12)
The present invention relates to particles for bioimaging, comprising up-conversion fluorescent nanoparticles and a carrier loaded with the up-conversion fluorescent nanoparticles, wherein the carrier is a micelle formed by a phosphate surfactant. According to the present invention, the particles for bioimaging are capable of releasing up-conversion nanoparticles (UCNP) in a specific location in vivo, thereby being capable of delivering the UCNP in a low concentration, and thus can significantly reduce adverse side effects in vivo; can improve dispersibility in vivo; and can have high selectivity to specific cells such as prostate cancer cells. Thus, the particles for bioimaging may be beneficially used as a marker substance for bioimaging.(AA) Phospholipase A_2(BB) UCNP-loaded micelle(CC) PEGylated ethylene glycol phosphate(DD) Stearic acid(EE) Upconversion nanoparticles (UCNPs)(FF) Extracellular space(GG) Cell membrane(HH) Intracellular spaceCOPYRIGHT KIPO 2018
DIOLIC PHOSPHOLIPIDS. IV. NEW SYNTHESIS OF DIOLIC PHOSPHATIDIC ACIDS
Nifant'ev, E. E.,Predvoditelev, D. A.,Rasadkina, E. N.,Kozlova, G. G.
, p. 424 - 427 (2007/10/02)
A new method for the synthesis of diolic phosphatidic acids is proposed that is based on the alkylation of potassium salts of higher carboxylic acids by cyclic alkylene phosphates. The initial compounds for the phospholipid synthesis, namely neutral alkylene phosphates and amidophosphates, are prepared by the Todd-Atherton oxidative phosphorylation of morpholine and trichloroethanol by ethylene and trimethylene phosphates.
DIOLIC PHOSPHOLIPIDS. II. SYNTHESIS OF DIOLIC PHOSPHATIDIC ACIDS AND THEIR THIOANALOGS
Rasadkina, E. N.,Predvoditelev, D. A.,Kozlova, G. G.,Nifant'ev, E. E.
, p. 431 - 436 (2007/10/02)
As a result of the oxidative phosphorylation of diols by dialkyl phosphites only the monophosphorylated diols are formed.The obtained hydroxyethyl (propyl) dimethyl and diethyl phosphates were acylated by stearoyl chloride and were converted by removal of the protecting alkyl groups into stearoyloxyethyl(propyl)phosphoric acid.A method was developed for the synthesis of the thio analogs of diolic phosphatidic acids with the use of an ethylene protecting group, which was removed with potassium cyanide.
