99897-26-4

Upstream product

• 99897-27-5 Toluene-4-sulfonic acid 3-trimethylsilanylmethyl-but-3-enyl ester 
• 86341-37-9 3-(Trimethylsilanylmethyl)but-3-en-1-ol 
• 58489-52-4 N-methyl-3-(3,4-dimethoxyphenyl)succinimide 
• 99897-25-3 N-methyl-3-(3,4-dimethoxyphenyl)-3-<3-(trimethylsilylmethyl)but-3-en-1-yl>succinimide 

Downstream Products

• 99897-28-6 7-aza-7-methyl-8-oxo-1-(3,4-dimethoxyphenyl)-4-methylenbicyclo<3.4.0>nonane 
• 21104-34-7 N-methyl-3a-<3,4-(dimethoxy)phenyl>-2,3,3a,4,5,6,7,7a-octahydroindole-2,6-dione 

Relevant academic research and scientific papers

INTRAMOLECULAR CYCLIZATION OF ALLYLSILYL SUBSTITUTED N-ACYLIMINIUM IONS. ACCESS TO 1- AND 2-AZABICYCLOALKANES. TOTAL SYNTHESIS OF (+/-)-MESEMBRINE

Access to 1- and 2-azabicycloalkanes by intramolecular cyclization of allylsilanes on α-acyliminium ions is described.This methodology is also used to achieve a highly stereoselective total synthesis of (+/-)-mesembrine.

CYCLISATION OF ALLYL SILANES. FORMAL TOTAL SYNTHESIS OF (+/-)-MESEMBRINE

The intramolecular reaction of an α-acyl iminium ion with an allyl silane occurs under non acidic conditions to afford the key intermediate 8 for the synthesis of (+/-)-mesembrine 1 in a stereospecific manner.