99897-27-5

Upstream product

• 62477-64-9 4-[(trimethylsilyl)methyl]but-3-enoic acid 
• 86341-37-9 3-(Trimethylsilanylmethyl)but-3-en-1-ol 
• 98-59-9 p-toluenesulfonyl chloride 
• 763-32-6 2-methyl-1-buten-4-ol 
• 75-77-4 chloro-trimethyl-silane 

Downstream Products

• 99897-25-3 N-methyl-3-(3,4-dimethoxyphenyl)-3-<3-(trimethylsilylmethyl)but-3-en-1-yl>succinimide 
• 1315327-79-7 C₁₇H₂₁N 
• 1315327-78-6 C₁₇H₂₁N 
• 1315327-94-6 N,N-bis(3-((trimethylsilyl)methyl)but-3-enyl)benzamide 
• 140136-29-4 [1-(1-Benzenesulfonyl-1H-indol-3-yl)-meth-(E)-ylidene]-(3-trimethylsilanylmethyl-but-3-enyl)-amine 
• 99897-26-4 1-methyl-4-(3,4-dimethoxyphenyl)-4-<3-(trimethylsilylmethyl)but-3-en-1-yl>-5-hydroxy-2-pyrrolidone 
• 166531-28-8 (R)-2-Phenyl-2-(3-trimethylsilanylmethyl-but-3-enylamino)-ethanol 

Relevant academic research and scientific papers

BIFUNCTIONAL ANNULATING REAGENTS: THE USE OF NOVEL ALLYLSILANES FOR THE ONE-POT PREPARATION OF SIX AND SEVEN-MEMBERED RINGS

Preliminary details of a new strategy for the synthesis of five, six, and seven-membered rings by use of novel allylsilane reagents are described.

An efficient route to 4-(substituted benzyl)piperidines

A novel approach to 4-(substituted benzyl)piperidines has been developed. The key steps involve the cyclization of imines bearing an allylsilane in the side-chain followed by the palladium-catalyzed cross-coupling of the resulting 4-methylenepiperidine with organoboronic acids under an atmosphere of oxygen.

Synthesis of 2-(3-indolyl)-4-methylenepiperidines via intramolecular cyclization of allylsilanes

The synthesis of 2-(3-indolyl)-4-methylenepiperidines using an efficient formation of the piperidine ring by intramolecular reaction between an allylsilane group and an iminium ion is reported.

INTRAMOLECULAR CYCLIZATION OF ALLYLSILYL SUBSTITUTED N-ACYLIMINIUM IONS. ACCESS TO 1- AND 2-AZABICYCLOALKANES. TOTAL SYNTHESIS OF (+/-)-MESEMBRINE

Access to 1- and 2-azabicycloalkanes by intramolecular cyclization of allylsilanes on α-acyliminium ions is described.This methodology is also used to achieve a highly stereoselective total synthesis of (+/-)-mesembrine.

CYCLISATION OF ALLYL SILANES. FORMAL TOTAL SYNTHESIS OF (+/-)-MESEMBRINE

The intramolecular reaction of an α-acyl iminium ion with an allyl silane occurs under non acidic conditions to afford the key intermediate 8 for the synthesis of (+/-)-mesembrine 1 in a stereospecific manner.