99902-26-8

Basic information

• Product Name: (2R,6R)-6-methyl-2-(2'-phenylethyl)-1,3-dioxan-4-on
• Synonyms: (2R,6R)-6-methyl-2-(2'-phenylethyl)-1,3-dioxan-4-on
• CAS NO: 99902-26-8
• Molecular Weight: 220.268
• Mol File: 99902-26-8.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: (2R,6R)-6-methyl-2-(2'-phenylethyl)-1,3-dioxan-4-on(CAS DataBase Reference)
• NIST Chemistry Reference: (2R,6R)-6-methyl-2-(2'-phenylethyl)-1,3-dioxan-4-on(99902-26-8)
• EPA Substance Registry System: (2R,6R)-6-methyl-2-(2'-phenylethyl)-1,3-dioxan-4-on(99902-26-8)

Safety Data

• Hazardous Substances Data: 99902-26-8(Hazardous Substances Data)

Upstream product

• 104-53-0 3-phenyl-propionaldehyde 
• 625-72-9 (R)-3-hydroxybutyric acid 
• 24057-28-1 pyridinium p-toluenesulfonate 
• 108438-96-6 trimethylsilyl (R)-3-<(trimethylsilyl)oxy>butyrate 

Downstream Products

• 99922-49-3 (3R,5R)-5-cyano-3-methyl-7-phenyl-4-oxaheptansaeure 
• 107-93-7 (E)-but-2-enoic acid 
• 60340-28-5 (S)-1-phenyl-5-hexen-3-ol 
• 60340-28-5 (R)-1-phenyl-hex-5-en-3-ol 
• 112463-36-2 (3R,5S)-3-methyl-5-(2'-phenylethyl)-4-oxaoct-7-ensaeure 
• 99902-28-0 (3R,5R)-3-methyl-5-(2'-phenylethyl)-4-oxaoct-7-ensaeure 
• 99902-30-4 (3R,5R)-3-methyl-5-(2'-phenylethyl)-4-oxahept-6-insaeure 
• 99902-37-1 (3R,5R)-5-carbamoyl-3-methyl-7-phenyl-4-oxaheptansaeure 
• 91012-00-9 (R)-2-hydroxy-4-phenylbutanamid 
• 122908-65-0 (2R,5R,6R) 2 (2'-phenyl) ethyl-5 (N,N'-di-tert-butoxycarbonyl)hydrazino-6-methyl-1,3-dioxane-4-one 

Relevant articles and documents

A highly stereoselective synthesis of the 1β-methylcarbapenem key intermediate from (R)-3-hydroxybutyric acid

(3R,4R)-4-Acetoxy-3-[(R)-1-(formyloxy)ethyl]-2-azetidinone 6 could be prepared highly stereoselectivity from (R)-3-hydroxybutyric acid by employing the [2+2]-cycloaddition reaction of chlorosulfonyl isocyanate with the 2H,4H-1,3-dioxin derivative and the Baeyer-Villiger reaction accompanying novel cleavage of the acetal moiety. The Reformatsky reaction of 6 with sterically crowded 3-(2-bromopropionyl)-2-oxazolidone derivatives readily afforded the title key intermediate after sequential chemical manipulations.

ELECTROPHILIC AMINATION: ENANTIOSELECTIVE SYNTHESES OF D-ALLOTHREONINE AND L-THREONINE

Starting from inexpensive polyhydroxybutanoate (PHB), D-allothreonine 1 and L-threonine 2 were synthetized by a sequence involving a diastereoselective electrophilic amination.When (R) 3-hydroxybutanoic acid was protected as dioxanone 9 very good yield (>95percent) and high diastereomeric excess (>99percent) were obtained in the amination step.

Optisch aktive Alkohole aus 1,3-Dioxan-4-onen; eine praktikable Variante der asymmetrischen Synthese unter nucleophiler Substitution an Acetalzentren

-