99902-77-9Relevant academic research and scientific papers
Synthesis and anti-CVB 3 evaluation of substituted 5-nitro-2-phenoxybenzonitriles
Puerstinger, Gerhard,De Palma, Armando M.,Zimmerhofer, Guenther,Huber, Simone,Ladurner, Sophie,Neyts, Johan
experimental part, p. 5123 - 5125 (2009/04/16)
The synthesis and SAR of a series of 60 substituted 2-phenoxy-5-nitrobenzonitriles (analogues of MDL-860) as inhibitors of enterovirus replication (in particular of coxsackievirus B3 (CVB 3)) are reported. Several of the analogues inhibited CVB 3 and othe
Antipicornavirus activity of substituted phenoxybenzenes and phenoxypyridines
Markley,Tong,Dulworth,Steward,Goralski,Johnston,Wood,Vinogradoff,Bargar
, p. 427 - 433 (2007/10/02)
Phenoxybenzenes and phenoxypyridines were prepared and tested for the effect of substituents on antipicornavirus activity. The most active compound, 2-(3,4-dichlorophenoxy)-5-nitrobenzonitrile (8), demonstrated broad-spectrum antipicornavirus activity. Co
