99916-98-0Relevant articles and documents
Structure-based design and synthesis of potent, ethylenediamine-based, mammalian farnesyltransferase inhibitors as anticancer agents
Fletcher, Steven,Keaney, Erin Pusateri,Cummings, Christopher G.,Blaskovich, Michelle A.,Hast, Michael A.,Glenn, Matthew P.,Chang, Sung-Youn,Bucher, Cynthia J.,Floyd, Ryan J.,Katt, William P.,Gelb, Michael H.,Van Voorhis, Wesley C.,Beese, Lorena S.,Sebti, Said M.,Hamilton, Andrew D.
experimental part, p. 6867 - 6888 (2010/12/18)
A potent class of anticancer, human farnesyltransferase (hFTase) inhibitors has been identified by "piggy-backing" on potent, antimalarial inhibitors of Plasmodium falciparum farnesyltransferase (PfFTase). On the basis of a 4-fold substituted ethylenediam
