99933-48-9

Basic information

• Product Name: Benzoic acid cyano-phenyl-quinazolin-4-yl-methyl ester
• Synonyms: Benzoic acid cyano-phenyl-quinazolin-4-yl-methyl ester
• CAS NO: 99933-48-9
• Molecular Weight: 365.391
• Mol File: 99933-48-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Benzoic acid cyano-phenyl-quinazolin-4-yl-methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Benzoic acid cyano-phenyl-quinazolin-4-yl-methyl ester(99933-48-9)
• EPA Substance Registry System: Benzoic acid cyano-phenyl-quinazolin-4-yl-methyl ester(99933-48-9)

Safety Data

• Hazardous Substances Data: 99933-48-9(Hazardous Substances Data)

Upstream product

• 5190-68-1 4-chloroquinazoline 
• 4242-46-0 1-cyanobenzyl benzoate 

Downstream Products

• 36082-71-0 quinazoline-4-carbonitrile 
• 65-85-0 benzoic acid 
• 55276-35-2 phenyl(quinazolin-4-yl)methanone 

Relevant articles and documents

Reaction of 4-Aroylquinazolines with Sodium Hydroxide: Aryl Migration to Give 4-Aryl-3,4-dihydro-4-quinazolinecarboxylic Acids and Formation of Quinazoline and Aroic Acids

4-Aroylquinazolines (3) were prepared in good yields by alkaline hydrolysis of α-aryl-4-quinazolinylmethyl benzoates (15), followed by oxidation.The reaction of 3 with sodium hydroxide in dimethyl sulfoxide(DMSO) was found to proceed in two ways.One path is the aryl migration to lead to 4-aryl-3,4-dihydro-4-quinazolinecarboxylic acids (4), and the other is the fission of the C4-CO bond to yield quinazoline (5) and aroic acids (6). Potassium ferricyanide oxidized the carboxylic acids 4 to the corresponding 4-arylquinazolines (14) with elimination of carbon dioxide. Reaction of 4-benzoylquinazoline (3a) with methylmagnesium iodide did not result in the migration, but instead yielded of α-methyl-α-phenyl-4-quinazolinemethanol (18) and 3,4-dihydro-α,4-dimethyl-α-phenyl-4-quinazolinemethanol (19).