99948-46-6Relevant articles and documents
Transition-Metal-Free α-Arylation of Enolizable Aryl Ketones and Mechanistic Evidence for a Radical Process
Pichette Drapeau, Martin,Fabre, Indira,Grimaud, Laurence,Ciofini, Ilaria,Ollevier, Thierry,Taillefer, Marc
, p. 10587 - 10591 (2015)
The α-arylation of enolizable aryl ketones can be carried out with aryl halides under transition-metal-free conditions using KOtBu in DMF. The α-aryl ketones thus obtained can be used for step- and cost-economic syntheses of fused heterocycles and Tamoxifen. Mechanistic studies demonstrate the synergetic role of base and solvent for the initiation of the radical process.
Terminal olefins to chromans, isochromans, and pyrans via allylic C-H oxidation
Ammann, Stephen E.,Rice, Grant T.,White, M. Christina
supporting information, p. 10834 - 10837 (2014/08/18)
The synthesis of chroman, isochroman, and pyran motifs has been accomplished via a combination of Pd(II)/bis-sulfoxide C-H activation and Lewis acid co-catalysis. A wide range of alcohols are found to be competent nucleophiles for the transformation under uniform conditions (catalyst, solvent, temperature). Mechanistic studies suggest that the reaction proceeds via initial C-H activation followed by a novel inner-sphere functionalization pathway. Consistent with this, the reaction shows reactivity trends orthogonal to those of traditional Pd(0)-catalyzed allylic substitutions.
Simple and efficient method for tetrahydropyranylation of alcohols and phenols by using silica supported sodium hydrogen sulphate as a catalyst
Ravi Kumar,Satyanarayana,Srinivasa Reddy
experimental part, p. 3876 - 3878 (2012/09/21)
A Simple and efficient process for tetrahydropyranylation of alcohols and phenols has been developed by reacting with dihydropyran at room temperature in presence of catalytic amount of silica supported sodium hydrogen sulphate.
Silicon- and sulfur-mediated synthesis of benzoannulated cyclooctanols
Genrich, Florian,Schaumann, Ernst
scheme or table, p. 6187 - 6190 (2010/01/03)
The reaction of a silyl-substituted thioacetal with ortho-difunctionalized benzenes as biselectrophiles allows access to multifunctional cyclooctanols.
Aza Hopf cyclization: synthesis and reactivity of cyclic azadieneynes
Mandal, Sayantan,Basak, Amit
scheme or table, p. 3641 - 3644 (2009/09/30)
Nine- and 10-membered azadieneynes have been synthesized for the first time via an intramolecular aza Wittig reaction. The compounds undergo Hopf cyclization under ambient conditions to the hydroxy dihydroisoquinoline derivatives.
Concise synthesis of pentenyl phenyl acrylic acid
Sun, Dequn,Lai, Pengxiang,Xie, Weidong,Deng, Jingen,Jiang, Yaozhong
, p. 2989 - 2994 (2008/02/12)
Pentenyl phenyl acrylic acid is a structural unit of pepticinnamin E, a natural product and a bisubstrate inhibitor of FPTase. In this article, a new synthetic strategy was developed to prepare pentenyl phenyl acrylic acid with high stereoselectivity and
Lithium tetrafluoroborate-in acetonitrile (LTAN) catalyzed Ferrier rearrangement - Facile synthesis of alkyl 2,3-unsaturated glycopyranosides?
Babu, B. Sobhana,Balasubramanian
, p. 1261 - 1262 (2007/10/03)
Treatment of 3,4-dihydro-2H-pyran 1 with various alcohols 2 - 10 furnished the tetrahydropyranyl ethers 11 - 19 in the presence of lithium tetrafluoroborate in acetonitrile (LTAN).
Synthesis and Biological Activities of Aryl Propargyl Sulfone
Wu, Ming-Jung,Lin, Chi-Fong,Chang, Li-Juan,Jing, Pao-Tzu,Duh, Tsai-Hui,Tseng, Wuan-Ting,Lee, Fang-Chen,Wang, Shan-Shue,Chang, Hsueh-O.
, p. 783 - 788 (2007/10/03)
A series of molecules containing monopropargyl sulfone or 1,2-bis-propargyl sulfone were synthesized. The cytotoxicity of these compounds against human carcinoma cells was also examined. This study indicated that the formation of a biradical intermediate
Diastereoselektive chelatkontrollierte Radikalcyclisierung eines chiralen, von Oxazolidinon abgeleiteten 2-Alkenamids und Modellierung des Uebergangszustands dieser Reaktion
Badone, Domenico,Bernassau, Jean-Marie,Cardamone, Rosanna,Guzzi, Umberto
, p. 575 - 578 (2007/10/03)
Keywords: Asymmetrische Synthesen; Kraftfeldrechnungen; Oxazolidinone; Radikale; Tetraline