99972-91-5

Basic information

• Product Name: 2-[(ethoxycarbonyl)oxy]-1H-isoindole-1,3(2H)-dione
• Synonyms: 2-[(ethoxycarbonyl)oxy]-1H-isoindole-1,3(2H)-dione
• CAS NO: 99972-91-5
• Molecular Formula: C₁₁H₉NO₅
• Molecular Weight: 235.19286
• Mol File: 99972-91-5.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-[(ethoxycarbonyl)oxy]-1H-isoindole-1,3(2H)-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 2-[(ethoxycarbonyl)oxy]-1H-isoindole-1,3(2H)-dione(99972-91-5)
• EPA Substance Registry System: 2-[(ethoxycarbonyl)oxy]-1H-isoindole-1,3(2H)-dione(99972-91-5)

Safety Data

• Hazardous Substances Data: 99972-91-5(Hazardous Substances Data)

Upstream product

• 64-17-5 ethanol 
• 78816-91-8 bis(1,3-dioxoisoindolin-2-yl)carbonate 
• 541-41-3 chloroformic acid ethyl ester 
• 524-38-9 N-hydroxyphthalimide 
• 70206-52-9 sodium salt of 2-hydroxy-1H-isoindole-1,3(2H)-dione 

Relevant articles and documents

Highly Active Manganese to C?O Cross-Coupling Reaction for the Synthesis of N-Hydroxyphthalimide Esters

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Synthesis and evaluation of potent KCNQ2/3-specific channel activators

KQT-like subfamily (KCNQ) channels are voltage-gated, non-inactivating potassium ion channels, and their down-regulation has been implicated in several hyperexcitability-related disorders, including epilepsy, neuropathic pain, and tinnitus. Activators of these channels reduce the excitability of central and peripheral neurons, and, as such, have therapeutic utility. Here, we synthetically modified several moieties of the KCNQ2-5 channel activator retigabine, an anticonvulsant approved by the U.S. Food and Drug Administration. By introducing a CF3-group at the 4-position of the benzylamine moiety, combined with a fluorine atom at the 3-position of the aniline ring, we generated Ethyl (2-amino-3-fluoro-4-((4-(trifluoromethyl)benzyl)amino)phenyl)carbamate (RL648-81), a new KCNQ2/3-specific activator that is >15 times more potent and also more selective than retigabine. We suggest that RL648-81 is a promising clinical candidate for treating or preventing neurologic disorders associated with neuronal hyperexcitability.

Synthesis and Anticonvulsant Activity of Imidooxy Derivatives

Previous results of anticonvulsant activity in several imidooxy carboxylates related to (aminooxy)acetic acid in young chicks, prompted an in-depth reinvestigation of these analogues in mice.A series of 22 succinimidooxy, phthalimidooxy, and naphthalimido