99973-69-0

Basic information

• Product Name: 2,4-diamino-6-(4-chlorophenyl)-5-pyrimidinecarbonitrile
• Synonyms: 2,4-diamino-6-(4-chlorophenyl)-5-pyrimidinecarbonitrile
• CAS NO: 99973-69-0
• Molecular Weight: 245.671
• Mol File: 99973-69-0.mol
• Article Data: 11

Chemical Properties

• CAS DataBase Reference: 2,4-diamino-6-(4-chlorophenyl)-5-pyrimidinecarbonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4-diamino-6-(4-chlorophenyl)-5-pyrimidinecarbonitrile(99973-69-0)
• EPA Substance Registry System: 2,4-diamino-6-(4-chlorophenyl)-5-pyrimidinecarbonitrile(99973-69-0)

Safety Data

• Hazardous Substances Data: 99973-69-0(Hazardous Substances Data)

Usage

General Description

The chemical compound 2,4-diamino-6-(4-chlorophenyl)-5-pyrimidinecarbonitrile, also known as ralimetinib, is a pyrimidine-based inhibitor with potential antineoplastic activity. It selectively inhibits MEK1/2, a group of kinases within the MAPK/ERK pathway that are often dysregulated in cancer cells, thereby suppressing the proliferation of cancer cells. Ralimetinib is being investigated for its potential in treating various types of cancer, including solid tumors and hematological malignancies, both as a monotherapy and in combination with other anticancer agents. Its specific molecular structure allows it to effectively target cancer cells while minimizing toxicity to normal cells, making it a promising candidate for cancer treatment.

Upstream product

• 1867-38-5 4-chlorobenzylidenemalonodinitrile 
• 50-01-1 guanidine hydrochloride 
• 104-88-1 4-chlorobenzaldehyde 
• 109-77-3 malononitrile 
• 124-46-9 guanidine hydrogen carbonate 
• 111509-94-5 3-(4-Chlorophenyl)-2-cyano-3-morpholinoacrylonitrile 
• 593-85-1 diguanidine carbonate 

Relevant articles and documents

A highly efficient synthesis of 2,4-diamino-6-arylpyrimidine-5-carbonitrile derivatives using NiCo2O4@Ni(BDC) metal-organic frameworks as a novel and bifunctional catalyst

The NiCo2O4@Ni(BDC) metal-organic frameworks as a suitable and green catalyst have been developed for the one-pot synthesis of 2,4-diamino-6-arylpyrimidine-5-carbonitrile derivatives. The multi-component reactions of aldehydes, malon

Facile Synthesis of Some Novel Tetrasubstituted 2,4-Diaminopyrimidine Derivatives in Aqueous Glucose Solution as a Fully Green Medium and Promoter

A novel environmentally benign method toward the synthesis of some novel tetrasubstituted 2,4-diaminopyrimidine derivatives using an aqueous glucose-mediated one-pot three-component reaction of malononitrile with various benzaldehyde and amidine derivatives is reported. Some pyrimidine derivatives possessing α-amino acid moiety were synthesized by the present protocol for the first time. This protocol offers advantages including facile reaction conditions, using naturally occurring glucose as promoter and water as solvent, simple work-up, relatively short reaction times, and high yields of the products.

Microwave-assisted one-pot synthesis of functionalized pyrimidines using ionic liquid

An efficient one-pot multicomponent synthesis of 2,4-diamino-5- pyrimidinecarbonitrile derivatives has been achieved in excellent yields by the condensation of aromatic aldehydes, malononitrile, and guanidine using ionic liquid under controlled microwave irradiation (100 W) at 60°C. This green approach offers a number of advantages in terms of methodology, high-product yield, short reaction time, mild reaction conditions, and easy workup.