99980-40-2

Basic information

• Product Name: 1-METHYL-1-PYRIDIN-3-YL-ETHYLAMINE
• Synonyms: 3-PYRIDINEMETHANAMINE, ALPHA,ALPHA-DIMETHYL-;1-METHYL-1-PYRIDIN-3-YL-ETHYLAMINE;3-Pyridinemethanamine,alpha,alpha-dimethyl-(9CI);a,a-diMethyl-3-PyridineMethanaMine;2-(Pyridin-3-yl)propan-2-aMine;2-(3-Pyridyl)-2-propanaMine;3-Pyridinemethanamine, α,α-dimethyl-;alpha,alpha-Dimethyl-3-pyridinemethanamine
• CAS NO: 99980-40-2
• Molecular Formula: C8H12N2
• Molecular Weight: 136.19428
• Product Categories: PYRIDINE
• Mol File: 99980-40-2.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 110 °C(Press: 15 Torr)
• Appearance: /
• Density: 0.997±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C(protect from light)
• PKA: 8.81±0.25(Predicted)
• CAS DataBase Reference: 1-METHYL-1-PYRIDIN-3-YL-ETHYLAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-METHYL-1-PYRIDIN-3-YL-ETHYLAMINE(99980-40-2)
• EPA Substance Registry System: 1-METHYL-1-PYRIDIN-3-YL-ETHYLAMINE(99980-40-2)

Safety Data

• Hazardous Substances Data: 99980-40-2(Hazardous Substances Data)

Usage

General Description

1-Methyl-1-pyridin-3-yl-ethylamine is a chemical compound with the formula C9H13N. It is a member of the ethylamine class of compounds and contains a pyridine ring attached to an ethylamine side chain. The compound is commonly used as a building block in organic synthesis and pharmaceutical research, where it serves as a precursor for the production of a variety of different drugs and active pharmaceutical ingredients. 1-Methyl-1-pyridin-3-yl-ethylamine exhibits both basic and nucleophilic properties, making it useful in a wide range of chemical reactions. Despite its potential uses, the compound should be handled with caution due to its potential health hazards and risks of toxicity if not used properly.

Upstream product

• 100-54-9 pyridine-3-carbonitrile 
• 917-54-4 methyllithium 

Downstream Products

• 1539276-42-0 N-[(1S,2R)-1-benzyl-2-hydroxy-3-(1-methyl-1-pyridin-3-ylethylamino)propyl]-5-piperidin-1-yl-N',N'-dipropylisophthalamide 

Relevant articles and documents

NITROGEN-CONTAINING SATURATED HETEROCYCLIC COMPOUND

The present invention provides a compound represented by the following formula (I) or its pharmaceutically acceptable salt: [wherein, R1 represents optionally substituted C1-4 alkyl, n shows integer of 1 to 4, R2 represents optionally substituted C1-4 alkyl or hydrogen atom, R3 represents optionally substituted C1-4 alkyl, R4a, R4b, R4c, and R4d, similarly or differently, represent optionally substituted C6-14 aryl, optionally substituted C1-4 alkyl, or hydrogen atom and the like, A represents optionally substituted C6-14 aryl or optionally substituted 5 to 11 membered heteroaryl].

Plasmepsin inhibitory activity and structure-guided optimization of a potent hydroxyethylamine-based antimalarial hit

Antimalarial hit 1SR (TCMDC-134674) identified in a GlaxoSmithKline cell based screening campaign was evaluated for inhibitory activity against the digestive vacuole plasmepsins (Plm I, II, and IV). It was found to be a potent Plm IV inhibitor with no selectivity over Cathepsin D. A cocrystal structure of 1SR bound to Plm II was solved, providing structural insight for the design of more potent and selective analogues. Structure-guided optimization led to the identification of structurally simplified analogues 17 and 18 as low nanomolar inhibitors of both, plasmepsin Plm IV activity and P. falciparum growth in erythrocytes.