99985-60-1Relevant articles and documents
Synthesis of γ-Amino Esters by Copper-Catalyzed Intermolecular 1,2-Aminoalkylation of Alkenes with Amines and α-Bromoalkyl Esters
Pan, Gao-Hui,Song, Ren-Jie,Xie, Ye-Xiang,Luo, Shenglian,Li, Jin-Heng
, p. 1651 - 1660 (2018)
A new copper-catalyzed intermolecular 1,2-aminoalkylation of alkenes with α-bromoalkyl esters and amines for the synthesis of γ-amino esters is described. Employing the Cu(OTf) 2 and 2,2′-bipyridine catalytic system, the three-component reaction allows the formation of two new chemical bonds, including one C-C bond and one C-N bond, in a single reaction, and represents a new alkene difunctionalization using a radical strategy.