99987-73-2Relevant academic research and scientific papers
Ph3P/I2-mediated synthesis of N,N′,N″-substituted guanidines and 2-iminoimidazolin-4-ones from aryl isothiocyanates
Wangngae, Sirilak,Pattarawarapan, Mookda,Phakhodee, Wong
, p. 10331 - 10340 (2017)
A convenient one-pot procedure for the synthesis of acyclic and cyclic guanidines mediated by the Ph3P/I2 system is described. Sequential condensation of aryl isothiocyanates with amines followed by dehydrosulfurization and guanylation could lead to both symmetric and unsymmetric N,N′,N″-substituted derivatives. Through a tandem guanylation-cyclization, a series of 2-iminoimidazolin-4-ones could also be prepared in good yields from the reaction of aryl isothiocyanates with amino acid methyl esters.
The Kinetics and Mechanism of Aminolysis of Isothiocyanates
Satchell, Derek P. N.,Satchell, Rosemary S.
, p. 1415 - 1420 (2007/10/02)
A study of the kinetics of aminolysis of p-nitrophenyl isothiocyanate by n-butylamine, benzylamine, dibenzylamine, p-anisidine, m-toluidine, N-methylaniline, and p-chloroaniline in diethyl ether and isooctane as solvents has shown that many of the reactio
