1 - Product and Company Information

Product Name PYRENE, 98%
Product Number 185515
2 - Composition/Information on Ingredients

Product Name CAS # EC no Annex I
Index Number
PYRENE 129-00-0 204-927-3 None

Formula C16H10
Molecular Weight 202.26 AMU
Synonyms Benzo(def)phenanthrene * Coal tar pitch
volatiles:pyrene (OSHA) * Pyren (German) *
beta-Pyrene

3 - Hazards Identification

SPECIAL INDICATION OF HAZARDS TO HUMANS AND THE ENVIRONMENT
Very toxic to aquatic organisms, may cause long-term adverse
effects in the aquatic environment.

Not hazardous according to Directive 67/548/EC.

4 - First Aid Measures

AFTER INHALATION
If inhaled, remove to fresh air. If breathing becomes difficult,
call a physician.

AFTER SKIN CONTACT
In case of contact, immediately wash skin with soap and copious
amounts of water.

AFTER EYE CONTACT
In case of contact with eyes, flush with copious amounts of
water for at least 15 minutes. Assure adequate flushing by
separating the eyelids with fingers. Call a physician.

AFTER INGESTION
If swallowed, wash out mouth with water provided person is
conscious. Call a physician.
5 - Fire Fighting Measures

EXTINGUISHING MEDIA
Suitable: Water spray. Carbon dioxide, dry chemical powder, or
appropriate foam.

SPECIAL RISKS
Specific Hazard(s): Emits toxic fumes under fire conditions.

SPECIAL PROTECTIVE EQUIPMENT FOR FIREFIGHTERS
Wear self-contained breathing apparatus and protective clothing
to prevent contact with skin and eyes.

6 - Accidental Release Measures

PERSONAL PRECAUTION PROCEDURES TO BE FOLLOWED IN CASE OF LEAK OR SPILL
Evacuate area.

PROCEDURE(S) OF PERSONAL PRECAUTION(S)
Exercise appropriate precautions to minimize direct contact with
skin or eyes and prevent inhalation of dust.

METHODS FOR CLEANING UP
Sweep up, place in a bag and hold for waste disposal. Avoid
raising dust. Ventilate area and wash spill site after material
pickup is complete.

7 - Handling and Storage

HANDLING
Directions for Safe Handling: Avoid inhalation. Avoid contact
with eyes, skin, and clothing. Avoid prolonged or repeated
exposure.

STORAGE
Conditions of Storage: Keep tightly closed.

8 - Exposure Controls / Personal Protection

ENGINEERING CONTROLS
Safety shower and eye bath. Mechanical exhaust required.

GENERAL HYGIENE MEASURES
Wash thoroughly after handling.

PERSONAL PROTECTIVE EQUIPMENT
Respiratory Protection: Wear dust mask.
Hand Protection: Protective gloves.
Eye Protection: Chemical safety goggles.

9 - Physical and Chemical Properties

Appearance Physical State: Solid
Color: White
Form: Fine crystals

Property Value At Temperature or Pressure

pH N/A
BP/BP Range 390 - 395 ?C
MP/MP Range 151 ?C

Flash Point > 200 ?C
Flammability N/A
Autoignition Temp N/A
Oxidizing Properties N/A
Explosive Properties N/A
Explosion Limits N/A
Vapor Pressure N/A
SG/Density 1.21 g/cm3
Partition Coefficient Log Kow: 4.88
Viscosity N/A
Vapor Density N/A
Saturated Vapor Conc. N/A
Evaporation Rate N/A
Bulk Density 650 kg/l
Decomposition Temp. N/A
Solvent Content N/A
Water Content N/A
Surface Tension N/A
Conductivity N/A
Miscellaneous Data N/A
Solubility N/A

10 - Stability and Reactivity

STABILITY
Stable: Stable.
Materials to Avoid: Strong oxidizing agents.

HAZARDOUS DECOMPOSITION PRODUCTS
Hazardous Decomposition Products: Carbon monoxide, Carbon dioxide.

HAZARDOUS POLYMERIZATION
Hazardous Polymerization: Will not occur

11 - Toxicological Information

RTECS NUMBER: UR2450000

ACUTE TOXICITY
LD50
Oral
Rat
> 16,000 mg/kg

LD50
Oral
Rat
2700 mg/kg
Remarks: Sense Organs and Special Senses (Nose, Eye, Ear, and
Taste):Eye:Conjunctive irritation. Behavioral:Excitement.
Behavioral:Muscle contraction or spasticity.

LC50
Inhalation
Rat
170 mg/m3
Remarks: Sense Organs and Special Senses (Nose, Eye, Ear, and
Taste):Eye:Conjunctive irritation. Behavioral:Excitement.
Behavioral:Muscle contraction or spasticity.

LD50
Oral

 Mouse
800 mg/kg
Remarks: Sense Organs and Special Senses (Nose, Eye, Ear, and
Taste):Eye:Conjunctive irritation. Behavioral:Excitement.
Behavioral:Muscle contraction or spasticity.

LD50
Intraperitoneal
Mouse
514 MG/KG

IRRITATION DATA
Eyes
Rabbit
Remarks: Mild irritation effect

Skin
Rabbit
500 mg
24H
Remarks: Mild irritation effect

SIGNS AND SYMPTOMS OF EXPOSURE
Inhalation studies in animals have caused hepatic, pulmonary,
and intragastric pathologic changes. Neutrophil, leukocyte, and
erythrocyte levels also decreased. Cutaneous application caused
hyperemia, weight loss, and hematopoietic changes and
dermatitis. Chronic effects: leukocytosis.

ROUTE OF EXPOSURE
Skin Contact: May cause skin irritation.
Skin Absorption: May be harmful if absorbed through the skin.
Readily absorbed through skin.
Eye Contact: May cause eye irritation.
Inhalation: May be harmful if inhaled. Material may be
irritating to mucous membranes and upper respiratory tract.
Ingestion: May be harmful if swallowed.

TARGET ORGAN INFORMATION
Liver. Blood. Kidneys.

CHRONIC EXPOSURE - CARCINOGEN
Result: This product is or contains a component that is not
classifiable as to its carcinogenicity based on its IARC, ACGIH,
NTP, or EPA classification.

Mouse
Route of Application: Skin
Exposure Time: 3W
Result: Tumorigenic:Equivocal tumorigenic agent by RTECS
criteria. Skin and Appendages: Other: Tumors.

IARC CARCINOGEN LIST

Rating: Group 3

CHRONIC EXPOSURE - MUTAGEN
Result: Laboratory experiments have shown mutagenic effects.

Human
100 MG/L
Cell Type: fibroblast

 Unscheduled DNA synthesis

Human
100 UMOL/L
Cell Type: lymphocyte
Sister chromatid exchange

Human
12 UMOL/L
Cell Type: Other cell types
Mutation in mammalian somatic cells.

Rat
2500 UMOL/L
Cell Type: liver
Unscheduled DNA synthesis

Rat
10 MG/L
Cell Type: Embryo
Mutation in mammalian somatic cells.

Mouse
10100 NMOL/L (+S9)
Cell Type: lymphocyte
Mutation in microorganisms

Mouse
10 MG/L
Cell Type: Embryo
Morphological transformation.

Mouse
50 UMOL/L
Cell Type: lymphocyte
DNA damage

Mouse
1510 UMOL/L
Cell Type: lymphocyte
Mutation in mammalian somatic cells.

Hamster
10 MG/L
Cell Type: Embryo
Morphological transformation.

Hamster
62500 UG/L
Cell Type: kidney
Morphological transformation.

Hamster
100 UMOL/L
Cell Type: liver
Unscheduled DNA synthesis

Hamster
10 MG/L
Cell Type: lung
Cytogenetic analysis


12 - Ecological Information

N/A

ECOTOXICOLOGICAL EFFECTS
Test Type: EC50 Daphnia
Species: Daphnia magna
Time: 48 h
Value: 0.002 - 0.003 mg/l

Test Type: LC50 Fish
Species: Onchorhynchus mykiss (Rainbow trout)
Time: 96 h
Value: > 2 mg/l

13 - Disposal Considerations

SUBSTANCE DISPOSAL
Contact a licensed professional waste disposal service to dispose
of this material. Dissolve or mix the material with a combustible
solvent and burn in a chemical incinerator equipped with an
afterburner and scrubber. Observe all federal, state, and local
environmental regulations.

14 - Transport Information

RID/AD UN#: 3077
Class: 9
PG: III
Proper Shipping Name: Environmentally hazardous
substance, solid, n.o.s

IMDG
UN#: 3077
Class: 9
PG: III
Proper Shipping Name: Environmentally hazardous
substance, solid, n.o.s
Marine Pollutant: No
Severe Marine Pollutant: No
Technical Name: Required

IATA
UN#: 3077
Class: 9
PG: III
Proper Shipping Name: Environmentally hazardous
substance, solid, n.o.s
Inhalation Packing Group I: No
Technical Name: Required

15 - Regulatory Information

CLASSIFICATION AND LABELING ACCORDING TO EU DIRECTIVES
INDICATION OF DANGER: N
Dangerous for the environment.
R-PHRASES: 50/53
Very toxic to aquatic organisms, may cause long-term adverse
effects in the aquatic environment.
S-PHRASES: 60 61
This material and its container must be disposed of as

 hazardous waste. Avoid release to the environment. Refer to
special instructions/safety data sheets.

Not hazardous according to Directive 67/548/EC.

COUNTRY SPECIFIC INFORMATION

Germany
WGK: 2 (Self classification)

SWITZERLAN SWISS POISON CLASS: 3

16 - Other Information

WARRANTY
The above information is believed to be correct but does not
purport to be all inclusive and shall be used only as a guide. The
information in this document is based on the present state of our
knowledge and is applicable to the product with regard to
appropriate safety precautions. It does not represent any
guarantee of the properties of the product. Sigma-Aldrich Inc.,
shall not be held liable for any damage resulting from handling or
from contact with the above product. See reverse side of invoice
or packing slip for additional terms and conditions of sale.
Copyright 2005 Sigma-Aldrich Co. License granted to make unlimited
paper copies for internal use only.

DISCLAIME For R&D use only. Not for drug, household or other uses.





Pyrene