4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylicacid, 6-[[(2R)-2-amino-2-phenylacetyl]amino]-3,3-dimethyl-7-oxo-,(2,2-dimethyl-1-oxopropoxy)methyl ester, (2S,5R,6R)- MSDS CasNo.33817-20-8

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CAS : 33817-20-8

MSDS

 4-Thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid,
6-(2-amino-2-phenylacetamido)-3,3- dimethyl-7-oxo-,
hydroxymethyl ester, pivalate (ester), D-(-)-

CAS

 33817-20-8

SYNONYMS

 * Ampicillin pivaloyloxymethyl ester
* MK 191
* Pivaloylampicillin
* Pivaloyloxymethyl ampicillinate
* Pivampicillin

Catalog of Chemical Suppliers, Buyers, Custom Synthesis Companies And Equipment Manufacturers
[ 4-Thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid,6-(2-amino-2-phenylacetamido)-3,3- dimethyl-7-oxo-,hydroxymethyl ester, pivalate (ester), D-(-)- 33817-20-8 ]

                     *** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : XH8380000
CHEMICAL NAME           : 4-Thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid,
                          6-(2-amino-2-phenylacetamido)-3,3- dimethyl-7-oxo-,
                          hydroxymethyl ester, pivalate (ester), D-(-)-
CAS REGISTRY NUMBER     : 33817-20-8
LAST UPDATED            : 199706
DATA ITEMS CITED        : 3
MOLECULAR FORMULA       : C22-H29-N3-O6-S
MOLECULAR WEIGHT        : 463.60
WISWESSER LINE NOTATION : T45 ANV ESTJ CMVYZR& F1 F1 GVO1OVX1&1&1 &GH
COMPOUND DESCRIPTOR     : Drug
                          Human
SYNONYMS/TRADE NAMES :
   * Ampicillin pivaloyloxymethyl ester
   * MK 191
   * Pivaloylampicillin
   * Pivaloyloxymethyl ampicillinate
   * Pivampicillin
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - woman
DOSE/DURATION           : 900 mg/kg/90D-I
TOXIC EFFECTS :
   Behavioral - muscle weakness
   Musculoskeletal - other changes
   Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
   PGMJAO Postgraduate Medical Journal.  (Blackwell Scientific Pub. Ltd., POB
   88, Oxford, UK) V.1-    1925-  Volume(issue)/page/year: 68,932,1992
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : >6 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JOPHDQ Journal of Pharmacobio-Dynamics.  (Japan Pub. Trading Co. (USA), 1255
   Howard St., San Francisco, CA 94103)  V.1-    1978- Volume(issue)/page/year:
   1,310,1978
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 148 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JOPHDQ Journal of Pharmacobio-Dynamics.  (Japan Pub. Trading Co. (USA), 1255
   Howard St., San Francisco, CA 94103)  V.1-    1978- Volume(issue)/page/year:
   1,310,1978
 
                            *** END OF RECORD ***

PIVAMPICILLIN