DPP and R,R-disubstituted 2-pyrrolidinylmethanols

February 22, 2024

• Title:       

  DPP and R,R-disubstituted 2-pyrrolidinylmethanols

• Image Source:

  A direct and versatile access to α,α-disubstituted 2-pyrrolidinylmethanols by SmI2-mediated reductive coupling

• Mark:

  Figure 1

• Associated context:

  Enantiopure proline-derived molecules are widely used as the source of chirality in enantioselective catalysis.1 Among them, R,R-diphenyl-2-pyrrolidinylmethanol (DPP, Figure 1)was initially introduced for the preparation of oxazaborolidines, as catalysts for CBS enantioselective reduction of ketones.² More recently, R,R-disubstituted 2-pyrrolidinylmethanols and their derivatives have found new and promising applications as organocatalysts for different asymmetric transformations.^1,3