Enantiomers of a substitutionally labile yet configurationally stable chiral-at-metal IrIII complex

March 01, 2024

• Title:       

  Enantiomers of a substitutionally labile yet configurationally stable chiral-at-metal IrIII complex

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  Asymmetric catalysis with substitutionally labile yet stereochemically stable chiral-at-metal iridium(III) complex

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  Figure 1

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  Recently, we introduced inert chiral-at-metal iridium(III) complexes as asymmetric catalysts in which the catalysis is mediated through the ligand sphere. We hypothesized that the high configurational inertness of iridium(III) complexes might permit retaining metal-centered chirality even in the  presence of exchange-labile ligands, and we selected Λ-1 and Δ-1 for investigating the scope of asymmetric catalysis with reactive but configurationally stable chiral-at-metal complexes (Figure 1).