(-)ppp basic information

product name:	(-)ppp
synonyms:	picropodophyllin;(-)ppp;poly(2,5-bis(3-sulfonatopropoxy)-1,4-phenylene, disodium salt-alt-1,4-phenylene);nsc 36407, picropodophyllin, ppp, (5r,5as,8ar,9r)-9-hydroxy-5,8,8a,9-tetrahydro-5-(3,4,5-trimethoxyphenyl)furo[3μ,4μ:6,7]naphtho[2,3-d]-1,3-dioxol-6(5ah)-one;(5r,5as,8ar,9r)-5,8,8a,9-tetrahydro-9-hydroxy-5-(3,4,5-trimethoxyphenyl)-furo[3',4':6,7]naphtho[2,3-d]-1,3-dioxol-6(5ah)-one;igf-1r inhibitor, ppp;(5r,5as,8ar,9r)-9-hydroxy-5,8,8a,9-tetrahydro-5-(3,4,5-trimethoxyphenyl)fur[3′,4′:6,7]naphtho[2,3-d]-1,3-dioxol-6(5ah)-one;nsc 36407
cas:	477-47-4
mf:	c22h22o8
mw:	0
einecs:
product categories:	insulin-like growth factor-1 receptor inhibitor;picropodophyllin
mol file:	mol file

(-)ppp chemical properties

mp	225-227℃
density	1.370
storage temp.	2-8°c
solubility	h2o: soluble

safety information

hazard codes	xi,t
risk statements	36/37/38-68-25-21
safety statements	26-36-45-36/37
ridadr	un 3462 6.1/pg 2
wgk germany	3
rtecs	lv2510000

msds information

provider	language
sigmaaldrich	english

(-)ppp usage and synthesis

usage

insulin growth factor 1 receptor inhibitor, antineoplastic

biological activity

orally active insulin-like growth factor 1 receptor (igf1r) inhibitor that exhibits no activity at the insulin receptor, fgfr, pdgfr or egfr. inhibits igf1r autophosphorylation (ic 50 ~ 1 nm), increases the fraction of cells in the g 2 /m phase and upregulates apoptosis. exhibits antiproliferative effects in multiple cancer cell lines (ic 50 = 0.05 - 15 μ m), and has anticancer and antineovascularization activity in vivo .

company information

henan sunlake enterprise corporation is located in henan province , the central plain of china , which enjoys favorable geogeaphical position and convenient transportion. the com[any was established in june. 1998, until now having more than 18 years experience in manufacturing & exporting chemical raw material .

sunlake is a professional manufacturer engaged in producing and selling chemicals,including organic & inorganic chemicals , pigments & dyestuffs , water treatment chemicals , food & feed additives and others. these products have been being well exported to europe, southeast asia, the middle east ,africa, south america and some other countries and areas.

we sincerely welcome foreign friends to visit our plant for cooperation. with the idea of "quality first,credit priority, excellent service", we are highly acknowledged by customers for good quality and competitive price. more importantly , the company has a strong r & d team, who are professional engineers and scholars with ph. d. .so we are confident to serve you better with our high - quality products and professional team. we are taking great efforts to provide our customers with demanded goods and professional services, and continuously improve our core ability of competition and get the momentum for sustainable development, and finally make us being a reliable and professional supplier in international market.

we welcome any serious inquiries from all customers of the world, and sincerely hope to cooperate with you for a brilliant future!