1421373-65-0 AZD-9291 CAS NO.1421373-65-0

Min.Order Quantity:: 1 Metric Ton

Purity:: 98%

Port:: Shanghai

Payment Terms:: L/C,T/T,Other

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Product Details

Keywords

1421373-65-0
AZD-9291
98%

Quick Details

ProName: 1421373-65-0 AZD-9291
CasNo: 1421373-65-0
Molecular Formula: C28H33N7O2
Appearance: Solid
Application: General reagent/ pharmaceutical inte...
DeliveryTime: Prompt
PackAge: As required
Port: Shanghai
ProductionCapacity: 20 Metric Ton/Month
Purity: 98%
Storage: Room temperature
Transportation: By Sea/ By Air/ By Courier
LimitNum: 1 Metric Ton
Heavy metal: ppm
Grade: Industrial Grade,Food Grade,Pharma Gra...
Assay: 99%

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Details

azd-9291 basic information

uses

product name:	azd-9291
synonyms:	azd9291, >=98%;azd9291 (free base);osimertinib (azd-9291);zad9291;azd9291, osimertinib;azd9291 base;osimertinib base;n-(2-{[2-(dimethylamino)ethyl](methyl)amino}-4-methoxy-5-{[4-(1-methyl-1h-indol-3-yl)pyrimidin
cas:	1421373-65-0
mf:	c28h33n7o2
mw:	499.61
einecs:
product categories:	inhibitors;anticancer;azd9291;api
mol file:	1421373-65-0.mol

azd-9291 chemical properties

safety information

msds information

azd-9291 usage and synthesis

uses	azd-9291 (osimertinib) is a oral, third generation, small-molecule epidermal growth factor receptor (egfr) inhibitor and antineoplastic agent. in addition, it is a cytochrome p450 3a inhibitor, and cytochrome p450 3a4 inducer, and cytochrome p450 1a2 inducer, and breast cancer resistance protein inhibitor. it is used for the treatment of advanced non-small cell lung cancer (nsclc) where mutant egfr form (such as t790m) is often presented. through suppressing the egfr-mediated signalling, it cause cell death and inhibit tumour growth in related cancer cells.
description	azd-9291 (mesylate), also known as osimertinib, belongs to a third-generation egfr (epidermal growth factor receptor) inhibitor. it can be used for the treatment of locally advanced or metastatic non-small cell lung cancer (nsclc) in case when the cancer cells carry specific mutations (such as t790m) in the epidermal growth factor receptor. it takes effect through directly binding to the certain mutant forms of egfr (t790m, l858r, and exon 19 deletions) that are frequently found in nsclc, further causing poor prognosis for late-stage disease. since it spares wild type egfr during therapy, it has only limited toxicity.
definition	chebi: a member of the class of aminopyrimidines that is 4-(1-methylindol-3-yl)pyrimidin-2-amine in which one of the amino hydrogens is replaced by a 2-methoxy-4-[2-(dimethylamino)ethyl](methyl)amino-5-acrylamidophenyl group. used (as the mesylate salt) for treat ent of egfr t790m mutation positive non-small cell lung cancer.
uses	azd 9291 is an irreversible inhibitor of epidermal growth factor receptor (egfr) sensitizing and t790m resistance mutations (ic50s = 15-17 nm) while sparing the wild-type form of the receptor (ic50 = 480 nm). it binds the related igf1r and herg receptors with significantly reduced potency (ic50s = 2.9 and 16.2 μm, respectively). azd 9291 has been shown to inhibit tumor growth in a xenograft mouse model at oral doses of 5-10 mg/kg and has been tested clinically in patients with advanced egfr mutant non-small-cell lung cancer.[cayman chemical]
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