162635-04-3 Temsirolimus CAS NO.162635-04-3

temsirolimus chemical properties

melting point 99-101°c

density 1.21

fp 587.8℃

storage temp. -20°c freezer

solubility soluble in chloroform, methanol.

color white to off-white

merck 14,9142

safety information

safety statements 24/25

rtecs ve6257000

msds information

temsirolimus usage and synthesis

chemical properties white solid

uses ester analog of rapamycin

uses temsirolimus (cci-779) is a specific mtor inhibitor with ic50 of 1.76 μm.

uses temsirolimus is a semisynthetic macrocyclic lactone prepared from rapamycin by selective alkylation of the 42-hydroxy group with a protected bis(dihydromethyl)propionic acid, followed by deprotection. like all tacrolimus analogues, temsirolimus binds to receptor protein, fkbp12. the complex then binds to mtor preventing it from interacting with target proteins. temsirolimus is extensively cited in the literature with over 700 citations.

uses temsirolimus is a semisynthetic macrocyclic lactone prepared from rapamycin by selective acylation of the 42-hydroxy group with a protected bis(dihydromethyl)propionic acid, followed by deprotection. like all tacrolimus analogues, temsirolimus binds to receptor protein, fkbp12. the complex then binds to mtor preventing it from interacting with target proteins. temsirolimus is extensively cited in the literature with over 700 citations.